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Viral Recombination

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.

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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

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Published on: November 5, 2021

Experimental re-infected cats do not transmit SARS-CoV-2.

Natasha N Gaudreault¹, Mariano Carossino², Igor Morozov¹

¹Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.

Emerging Microbes & Infections

|March 11, 2021

Summary

Cats can be re-infected with SARS-CoV-2, but shed less virus and do not transmit it to other cats. Previous infection offers partial immunity against reinfection in felines.

Keywords:

COVID-19 SARS-CoV-2 cats re-infection transmission

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Published on: December 18, 2012

Area of Science:

Veterinary Virology
Infectious Diseases
Immunology

Background:

Cats are susceptible to SARS-CoV-2 infection and can transmit it to other cats.
Understanding feline immunity to SARS-CoV-2 is crucial for pandemic control.

Purpose of the Study:

To investigate if cats previously infected with SARS-CoV-2 can be re-infected.
To assess viral shedding and transmission potential after secondary SARS-CoV-2 challenge in cats.

Main Methods:

Cats were re-challenged with SARS-CoV-2 21 days after primary infection.
Viral RNA detection, clinical signs, and tissue histology were analyzed post-re-challenge.
Naïve sentinel cats were co-housed to assess transmission.

Main Results:

Re-challenged cats exhibited transient viral shedding, primarily in the upper respiratory tract.
Lower viral RNA levels and reduced tissue presence were observed compared to primary infection.
No transmission occurred to co-housed naïve sentinel cats.

Conclusions:

Cats develop partial, non-sterilizing immunity after SARS-CoV-2 infection, reducing but not eliminating susceptibility to re-infection.
Previous SARS-CoV-2 infection in cats limits viral shedding and prevents transmission to susceptible felines.