Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Viral Recombination

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.

Infection

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...

Steps in Outbreak Investigation

Steps in Outbreak Investigation

In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:

Principles of Disease Surveillance

Principles of Disease Surveillance

Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...

Causality in Epidemiology

Causality in Epidemiology

Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...

Transmission-based Precautions I: Contact, Enteric, and Droplets

Transmission-based Precautions I: Contact, Enteric, and Droplets

Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Distribution, host records, and Rickettsia species -associated with Dermacentor parumapertus (Acari: Ixodidae) in western North America.

Journal of medical entomology·2026

Same author

Area Deprivation and Social Vulnerability Are Associated with Pediatric Vision Screening Outcomes in the University of California, Irvine EyeMobile Program.

Eye (London, England)·2026

Same author

Rickettsia lanei Rickettsiosis, Oregon, USA, 2025.

Emerging infectious diseases·2026

Same author

Rickettsia parkeri subverts nicotinamide adenine dinucleotide (NAD+) metabolic pathway for its survival in endothelial cells.

The FEBS journal·2026

Same author

Guinea Pig Model for Lassa Virus Infection of Reproductive Tract and Considerations for Sexual and Vertical Transmission.

Emerging infectious diseases·2026

Same author

Case of Congenital Tularemia with Neuroinvasive Disease, Utah, USA.

Emerging infectious diseases·2025

Search research articles

Related Experiment Video

Updated: Nov 14, 2025

Vector Competence Analyses on Aedes aegypti Mosquitoes using Zika Virus

Vector Competence Analyses on Aedes aegypti Mosquitoes using Zika Virus

Published on: May 31, 2020

Intersecting Paths of Emerging and Reemerging Infectious Diseases.

Tais M Wilson, Christopher D Paddock, Sarah Reagan-Steiner

Emerging Infectious Diseases

|March 11, 2021

Summary

During the SARS-CoV-2 pandemic, consider Hantavirus pulmonary syndrome in patients with severe respiratory distress. Differential diagnoses and co-infections are crucial for accurate diagnosis and treatment.

Keywords:

COVID-19 HPS Peromyscus maniculatus SARS-CoV-2 Sin Nombre virus co-infection coronavirus disease differential diagnoses hantavirus hantavirus pulmonary syndrome histopathology immunohistochemical analysis pathology respiratory infections severe acute respiratory syndrome coronavirus 2 vector-borne infections

More Related Videos

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

Experimental Viral Infection in Adult Mosquitoes by Oral Feeding and Microinjection

Experimental Viral Infection in Adult Mosquitoes by Oral Feeding and Microinjection

Published on: July 28, 2022

Related Experiment Videos

Last Updated: Nov 14, 2025

Vector Competence Analyses on Aedes aegypti Mosquitoes using Zika Virus

Vector Competence Analyses on Aedes aegypti Mosquitoes using Zika Virus

Published on: May 31, 2020

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

Experimental Viral Infection in Adult Mosquitoes by Oral Feeding and Microinjection

Experimental Viral Infection in Adult Mosquitoes by Oral Feeding and Microinjection

Published on: July 28, 2022

Area of Science:

Pulmonary Medicine
Infectious Diseases
Virology

Background:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents with symptoms overlapping other severe lung conditions.
The ongoing pandemic necessitates a broad differential diagnosis for respiratory illnesses.

Purpose of the Study:

To highlight the importance of considering Hantavirus pulmonary syndrome (HPS) in the differential diagnosis of severe respiratory illness during the SARS-CoV-2 pandemic.
To emphasize the need for evaluating co-infections in patients with critical respiratory conditions.

Main Methods:

Case review of two patients in Arizona diagnosed with Hantavirus pulmonary syndrome.
Clinical and pathological feature comparison between HPS and SARS-CoV-2.

Main Results:

Two cases of Hantavirus pulmonary syndrome were identified in patients initially suspected of having SARS-CoV-2 infection.
Clinicopathologic similarities between HPS and SARS-CoV-2 underscore diagnostic challenges.

Conclusions:

Hantavirus pulmonary syndrome should be considered in the differential diagnosis of severe respiratory distress, especially in endemic areas.
Thorough diagnostic evaluation, including testing for co-infections, is essential for patients presenting with critical respiratory symptoms during the COVID-19 pandemic.