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Dyslipidemia and rupture risk of intracranial aneurysms-a systematic review

Katja Løvik1, Johnny Laupsa-Borge2, Nicola Logallo3

  • 1Department of Clinical Medicine, University of Bergen, Bergen, Norway. katja.lovik@gmail.com.

Neurosurgical Review
|March 11, 2021
PubMed

Insights

Dyslipidemia

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Genetics

Background:

  • Dyslipidemia is a known risk factor for coronary artery disease.
  • Its impact on cerebral artery disease, specifically intracranial aneurysm rupture, remains unclear.
  • This systematic review addresses this knowledge gap.

Purpose of the Study:

  • To investigate the association between dyslipidemia and the incidence of aneurysmal subarachnoid hemorrhage (aSAH).
  • To explore the relationship between different types of dyslipidemia and intracranial aneurysm rupture risk.

Main Methods:

  • Systematic review of clinical trials identified via MEDLINE, Embase, and Web of Science.
  • Included studies compared rupture risk in subarachnoid hemorrhage patients with and without dyslipidemia.
  • Risk of bias assessed using the Critical Appraisal Skills Program (CASP).

Main Results:

  • Five case-control studies met eligibility criteria.
  • An inverse relationship observed between hypercholesterolemia and intracranial aneurysm rupture risk.
  • All included studies were classified as high risk of bias.

Conclusions:

  • Hypercholesterolemia appears associated with reduced intracranial aneurysm rupture risk.
  • The role of dyslipidemia versus antihyperlipidemic medication in this association requires further clarification.
  • Further high-quality research is needed to confirm these findings.

Keywords:
Aneurysmal subarachnoid hemorrhageCoronary artery diseaseDyslipidemiaHypercholesterolemiaIntracranial aneurysms

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