Related Experiment Videos
One stressful event blocks multiple actions of diazepam for up to at least a month
S M Antelman1, S Knopf, D Kocan
1Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, PA 15260.
Brain Research
|April 5, 1988
Abstract:
Based on recent findings of this laboratory, the hypothesis was tested that a single stressful encounter might have a persistent antidiazepam influence. Our results indicate that one exposure to a brief stressful event up to at least one month earlier prevented completely the effect of diazepam on pentylenetetrazole-induced changes in dopamine in the rat frontal cortex, elevations of plasma corticosterone levels and seizures.