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Updated: Nov 14, 2025

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Tooth Development Following Mandibular Distraction Osteogenesis in Neonates With Pierre Robin Sequence
1Department of Pediatric Dentistry, Brookdale Hospital and Medical Center.
Mandibular distraction osteogenesis can cause tooth development issues in children, including positional changes and root malformations. However, major complications are rare, and improved surgical planning may further reduce risks.
Area of Science:
- Pediatric surgery
- Craniofacial surgery
- Dental development
Background:
- Mandibular distraction osteogenesis (MDO) treats pediatric mandibular retrognathia and hypoplasia, often improving airway obstruction.
- This procedure is frequently performed in neonates and infants.
- Tooth development complications are a potential surgical risk.
Purpose of the Study:
- To systematically review long-term outcomes of MDO on pediatric tooth development.
- To identify the types and frequencies of dental anomalies following MDO.
Main Methods:
- Systematic literature search of PubMed and EMBASE databases.
- Review of retrospective studies on MDO and long-term tooth development outcomes.
- Data extraction on dental injury type, affected tooth, and occurrence frequency.
Main Results:
- Observed tooth injuries include positional changes (35%), shape alteration/fracture (24%), missing teeth (15%), root injury/malformation (14%), follicle/bud perforation (9%), delayed eruption (2%), and dentigerous cysts (1%).
- Permanent first molars are most frequently affected, followed by primary second molars.
- Third molars are the least commonly affected teeth.
Conclusions:
- Tooth injuries are documented after MDO in pediatric patients, but significant complications are infrequent.
- Advancements in presurgical planning are expected to minimize risks to primary and permanent tooth development.
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