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Updated: Nov 14, 2025
13:20
Flow Cytometric Measurement Of ROS Production In Macrophages In Response To FcγR Cross-linking
Published on: March 7, 2019
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Metabolic ROS Signaling: To Immunity and Beyond
A Y Andreyev1, Y E Kushnareva2, N N Starkova3
1The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA. alex_andreyev@mitoexperts.com.
Biochemistry. Biokhimiia
|March 11, 2021
Summary
This review explores immunometabolism and mitochondrial reactive oxygen species (ROS) signaling. We propose that regulatory ROS production is governed by mitochondrial biogenesis, not metabolic switches.
Area of Science:
- Immunology
- Cellular Metabolism
- Mitochondrial Biology
Background:
- Metabolism critically influences immune cell function.
- Immunometabolism integrates energy transduction and biochemical pathways.
- Mitochondria are key players in immune cell metabolic adaptation and signaling.
Purpose of the Study:
- To review the concepts of ROS signaling and immunometabolism from a bioenergetic perspective.
- To critically assess methodologies for ROS assessment in immunology.
- To propose a novel hypothesis regarding ROS regulation in immunity.
Main Methods:
- Literature review and analysis of existing data.
- Bioenergetic standpoint on ROS signaling and immunometabolism.
- Critical evaluation of ROS detection techniques.
Main Results:
- Mitochondria contribute to immune cell adaptation via ATP production and ROS signaling.
- Mitochondrial ROS have established roles in oxidative stress and emerging roles in immune signaling.
- Current ROS assessment methods present challenges.
Conclusions:
- Regulatory ROS production, distinct from oxidative stress, is hypothesized to be controlled by mitochondrial biogenesis.
- This contrasts with the established role of metabolic switches in immune cell activation.
- Further research is needed to validate the proposed regulatory mechanism.
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