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High expression of CD52 in adipocytes: a potential therapeutic target for obesity with type 2 diabetes

Rui Mao1, Fan Yang2, Yu Zhang1

  • 1The Center of Gastrointestinal and Minimally Invasive Surgery, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, China.

Aging
|March 11, 2021
PubMed

Insights

CD52 is upregulated in obesity and type 2 diabetes (T2DM). Downregulating CD52 improves glucose tolerance and insulin sensitivity, suggesting it

Area of Science:

  • Metabolism
  • Immunology
  • Endocrinology

Background:

  • Obesity and type 2 diabetes mellitus (T2DM) are complex metabolic disorders.
  • Understanding the molecular mechanisms linking obesity and T2DM is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the role of CD52 in adipocytes.
  • To explore the association between CD52 and T2DM in the context of obesity.
  • To elucidate potential molecular pathways involved in obesity with T2DM.

Main Methods:

  • Analysis of CD52 expression in adipocytes and preadipocytes from lean and obese individuals.
  • In vitro studies on CD52 mRNA levels during adipocyte differentiation.
  • In vivo studies using high-fat diet (HFD)-fed mice.
  • Correlation analysis of CD52 with TGF-β/Smad3 signaling pathway.
  • Comparison of gene expression in CD4+ T cell subsets.

Main Results:

  • CD52 mRNA was significantly upregulated in mature adipocytes and preadipocytes, increasing with differentiation.
  • CD52 expression was higher in HFD-fed mice compared to regular diet-fed mice.
  • CD52 expression positively correlated with Smad3 and TGF-β.
  • Downregulation of CD52 improved glucose tolerance and insulin sensitivity.
  • Aberrant expression of T2DM-related genes was observed in CD4+CD52high T cells compared to CD4+CD52low T cells.

Conclusions:

  • CD52 is implicated in the pathophysiology of obesity with T2DM.
  • CD52 may regulate T2DM through the TGF-β/Smad3 signaling pathway.
  • CD52 represents a potential therapeutic target for obesity and T2DM.
Keywords:
CD52T2DMTGF-βobesity

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