Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

136
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
136
Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

352
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
352
Heart Valves01:16

Heart Valves

9.7K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
9.7K
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

79
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
79
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

1.8K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.8K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

174
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
174

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of Iron in Neuronal Homeostasis: A Double-Edged Sword.

Cells·2026
Same author

Temporal Stratification of Atrial Fibrillation Detected After Stroke: Differences in Patient Characteristics and Prognostic Implications.

Journal of the American Heart Association·2026
Same author

Combined ultrasound-guided hyaluronic acid injections, high-power laser therapy and physiotherapy improve hip function in osteoarthritis: A randomized controlled trial.

Journal of experimental orthopaedics·2026
Same author

Mapping Echocardiographic Practice in Emilia-Romagna: A Regional Healthcare Census.

Journal of clinical medicine·2026
Same author

Fast and ultrafast charge transfer dynamics in organic dye sensitizers anchored on TiO<sub>2</sub> for photoelectrochemical cells.

Physical chemistry chemical physics : PCCP·2026
Same author

Alterations of right ventricular assessment by use of an ultrasound-enhancing agent during routine visualization of the left ventricle.

European heart journal. Imaging methods and practice·2026

Related Experiment Video

Updated: Nov 14, 2025

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

4.3K

Heart valve calcification and cardiac hemodynamics.

Andrea Rossi1, Andrea Barbieri2, Giovanni Benfari1

  • 1Section of Cardiology, Department of Medicine, School of Medicine, Verona, Italy.

Echocardiography (Mount Kisco, N.Y.)
|March 11, 2021
PubMed
Summary

Heart valve calcification (VC) is linked to poorer heart function and hemodynamics. This study found VC independently associated with impaired diastolic function and higher pulmonary artery pressure.

Keywords:
diastolic functionechocardiographyheart valve calcificationpulmonary artery pressure

More Related Videos

Isolation of Human Primary Valve Cells for In vitro Disease Modeling
07:31

Isolation of Human Primary Valve Cells for In vitro Disease Modeling

Published on: April 16, 2021

3.0K
Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

16.4K

Related Experiment Videos

Last Updated: Nov 14, 2025

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

4.3K
Isolation of Human Primary Valve Cells for In vitro Disease Modeling
07:31

Isolation of Human Primary Valve Cells for In vitro Disease Modeling

Published on: April 16, 2021

3.0K
Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

16.4K

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiovascular Disease

Background:

  • Heart valve calcification (VC) increases cardiovascular risk.
  • The hemodynamic and functional impact of VC requires further investigation.

Purpose of the Study:

  • To explore the hemodynamic and functional profile of patients with heart valve calcification (VC).
  • To determine the association between VC and echocardiographic parameters.

Main Methods:

  • A comprehensive echocardiographic examination was performed on 1098 consecutive patients.
  • VC was identified in 31% of the study population.
  • Multivariate models were used to assess independent associations.

Main Results:

  • Patients with VC were older and had more comorbidities like hypertension, diabetes, and coronary artery disease.
  • VC was associated with lower ejection fraction, worse diastolic function (elevated E/e'), and higher pulmonary artery pressure (PASP).
  • The association of VC with diastolic function and PASP remained significant after multivariate analysis.

Conclusions:

  • Heart valve calcification is associated with a worse functional and hemodynamic profile.
  • VC is independently linked to impaired diastolic function and elevated pulmonary artery pressure.