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Current community transmission and future perspectives on the COVID-19 process
Seyhan Türk1, Can Türk2, Ümit Yavuz Malkan3
1Department of Biochemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
Turkish Journal of Medical Sciences
|March 11, 2021
Summary
The SARS-CoV-2 virus may integrate into the human genome, becoming part of the intestinal virobiota. Chimerism-mediated immunotherapy and vaccination are proposed as the only solutions to conclude the COVID-19 pandemic.
Area of Science:
- Virology
- Genomics
- Immunology
Background:
- The COVID-19 pandemic caused by SARS-CoV-2 presents a global health challenge.
- Understanding the long-term implications of SARS-CoV-2 infection is crucial.
Purpose of the Study:
- To propose hypotheses regarding the conclusion of the COVID-19 pandemic.
- To investigate the potential integration of SARS-CoV-2 into the human genome.
Main Methods:
- Hypothesizing a three-phase pathobiological process (induction, consolidation, maintenance) for viral genomic incorporation.
- Utilizing a random walk model to predict virus transmission kinetics.
Main Results:
- SARS-CoV-2 RNA can be reverse-transcribed and integrated into the human genome.
- The virus may become an element of the intestinal virobiota.
- Chimerism-mediated immunotherapy and vaccination are identified as potential strategies to conclude the COVID-19 process.
Conclusions:
- Elucidating viral dynamics is key for long-term disease management.
- The integration of SARS-CoV-2 into the human genome is a proposed mechanism for its persistence.
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