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Updated: Nov 14, 2025
A Method to Study α-Synuclein Toxicity and Aggregation Using a Humanized Yeast Model
Published on: November 25, 2022
My Old World chap, this α-gal is not for you
Luis B Barreiro1, Alexander Chervonsky2
1Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL 60637, USA; Committee on Genetics, Genomics, and Systems Biology, The University of Chicago, Chicago, IL 60637, USA; Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA.
Abstract:
30 million years ago, ancestors of Old World primates lost the ability to produce α-gal. In this issue of Cell Host & Microbe, Singh et al. (2021) show that the loss is associated with increased resistance to sepsis, but that this advantage comes alongside a cost of accelerated reproductive senescence.
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