Related Experiment Video
Updated: Nov 14, 2025
Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice
Published on: January 19, 2018
Tumor microenvironment remodeling-based penetration strategies to amplify nanodrug accessibility to tumor parenchyma
Yanhong Liu1, Jiyuan Zhou1, Qiang Li1
1Department of Pharmaceutics, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China.
Abstract:
Remarkable advances in nano delivery systems have provided new hope for tumor prevention, diagnosis and treatment. However, only limited clinical therapeutic effects against solid tumors were achieved. One of the main reasons is the presence of abundant physiological and pathological barriers in vivo that impair tumoral penetration and distribution of the nanodrugs. These barriers are related to the components of tumor microenvironment (TME) including abnormal tumor vasculature, rich composition of the extracellular matrix (ECM), and abundant stroma cells. Herein, we review the advanced strategies of TME remodeling to overcome these biological obstacles against nanodrug delivery. This review aims to offer a perspective guideline for the implementation of promising approaches to facilitate intratumoral permeation of nanodrugs through alleviation of biological barriers. At the same time, we analyze the advantages and disadvantages of the corresponding methods and put forward possible directions for the future researches.
Insights
Strategies to remodel the tumor microenvironment (TME) can overcome biological barriers, improving nanodrug delivery for solid tumors. This review explores advanced TME remodeling approaches for enhanced cancer nanomedicine.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Nanodelivery systems offer promise for cancer therapy, but clinical success against solid tumors is limited.
- In vivo barriers, including abnormal tumor vasculature, extracellular matrix (ECM), and stroma cells, hinder nanodrug penetration and distribution.
- The tumor microenvironment (TME) presents significant obstacles to effective nanodrug delivery.
Purpose of the Study:
- To review advanced strategies for TME remodeling to overcome biological barriers in nanodrug delivery.
- To provide a guideline for implementing approaches that enhance intratumoral permeation of nanodrugs.
- To analyze the pros and cons of TME remodeling methods and suggest future research directions.
Main Methods:
- Literature review of TME remodeling strategies.
- Analysis of biological barriers within the tumor microenvironment.
- Evaluation of methods to alleviate these barriers for improved nanodrug delivery.
Main Results:
- TME remodeling strategies can effectively mitigate barriers like abnormal vasculature, dense ECM, and stroma cells.
- Targeted approaches can enhance nanodrug penetration and distribution within solid tumors.
- Various remodeling techniques show potential for improving therapeutic outcomes.
Conclusions:
- Overcoming TME-mediated biological barriers is crucial for advancing nanodrug delivery in solid tumors.
- Strategic TME remodeling offers a promising avenue for enhancing cancer nanomedicine efficacy.
- Further research into optimizing TME remodeling methods is warranted for clinical translation.
More Related Videos
10:01Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
Published on: August 2, 2022
09:42Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
Published on: June 26, 2019
