Related Experiment Video
Updated: Nov 14, 2025
Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
Published on: March 30, 2017
Dry powder pharmaceutical biologics for inhalation therapy
Rachel Yoon Kyung Chang1, Michael Y T Chow1, Dipesh Khanal1
1Advanced Drug Delivery Group, Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, NSW 2006, Australia.
Developing stable inhalable powders for therapeutic biologics, including proteins and nucleic acids, is crucial for respiratory medicine. This review highlights formulation and manufacturing strategies to ensure drug stability and effective pulmonary delivery.
Area of Science:
- Pharmaceutical Sciences
- Biotechnology
- Respiratory Medicine
Background:
- Therapeutic biologics offer significant clinical benefits for respiratory diseases.
- Pulmonary delivery enhances bioavailability and minimizes systemic toxicity.
- Inhalable powder formulation presents unique stabilization challenges for diverse biologics.
Purpose of the Study:
- To review formulation strategies for stabilizing proteins, nucleic acids, viruses, and cells in inhalable powders.
- To cover characterization methods for assessing powder properties and biologic integrity.
- To discuss manufacturing technologies for biologic inhalable powders.
Main Methods:
- Literature review of formulation strategies for various biologics.
- Examination of characterization techniques for physicochemical and biological properties.
- Analysis of manufacturing processes like lyophilization and spray-drying.
Main Results:
- Key formulation strategies are essential for stabilizing diverse biologics in inhalable powders.
- Comprehensive characterization methods are needed to ensure quality and performance.
- Lyophilization and spray-drying are viable manufacturing technologies for approved protein powders.
Conclusions:
- Formulating and manufacturing inhalable biologic powders is challenging but achievable.
- Biologic and powder stability, alongside powder dispersibility, are critical success factors.
- Appropriate excipients and manufacturing processes mitigate biologic degradation.
More Related Videos
04:59Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
Published on: August 18, 2023
07:28Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
Published on: April 6, 2017
Related Concept Videos
01:23Inhaled Medications
01:22Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
01:30Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
01:18Additional Routes of Drug Administration
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
01:17Drugs Used in Lower Respiratory Disorders: Overview
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...