Related Experiment Video
Updated: Nov 14, 2025
Author Spotlight: Minimally Invasive Ultrasound-Guided Acupotomy in Knee Osteoarthritis Treatment
Published on: April 26, 2024
Effectiveness of topical ozonated oil in severe osteoarthritis: A randomised, triple-blinded, placebo-controlled
Ana Paula Anzolin1, Diego da Silva Collares2, Renato Tadeu Dos Santos2
1Graduate Program in Human Aging, University of Passo Fundo, Passo Fundo, Rio Grande do Sul, Brazil.
Background:
Osteoarthritis is highly prevalent and a common locomotory disorder in the elderly. The treatments aim improves the quality of life. We aimed to evaluate the effectiveness of topical ozonated oil in relieving pain in patients with osteoarthritis.
Design:
A placebo-controlled, triple-blind, randomised controlled trial including osteoarthritis patients older than 50 years.
Interventions:
Eighty patients were randomly divided into two groups: treatment (ozonated oil) and placebo (non-ozonated oil). The oils were used twice a day for 60 days. Evaluations were performed using WOMAC (Western Ontario and McMaster Universities) and VAS (visual analogue scale) and laboratory analysis.
Results:
Pain relief was observed in all groups except in the placebo group where patients are diagnosed with severe osteoarthritis (degree 4) (p-value treatment and placebo group: 0.021 and 0.345, respectively).
Conclusions:
For the first time, the pain relief in patients with severe osteoarthritis was demonstrated by the use of topical ozonated oil.
