[First Cases of Multisystem Inflammatory Syndrome following SARS-CoV-2 infection in Adults in Germany]

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Karl Rieper1, Andreas Sturm2

  • 1DRK-Kliniken Berlin-Westend, Klinik für Innere Medizin, Schwerpunkt Kardiologie.

Deutsche Medizinische Wochenschrift (1946)
|March 11, 2021
PubMed
Abstract

Insights

Multisystem Inflammatory Syndrome in adults (MIS-A) can present with diverse symptoms following SARS-CoV-2 infection. Early consideration of MIS-A, including hydrocortisone and immunoglobulins, is crucial for managing severe cases and potential cardiac involvement.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Gastroenterology

Background:

  • Multisystem Inflammatory Syndrome in adults (MIS-A) is a rare post-SARS-CoV-2 complication, with limited reported cases in the US and UK.
  • This report details two adult MIS-A cases from Germany, highlighting geographical expansion and clinical diversity.

Observation:

  • Case 1: A 27-year-old male presented with fever, abdominal pain, and peritonism.
  • Case 2: A 21-year-old female presented with fever, headache, neck stiffness, and somnolence.

Findings:

  • Both patients exhibited elevated inflammatory markers and positive SARS-CoV-2 antibodies.
  • Case 1 showed ileitis and colitis; Case 2 presented with reduced left ventricular ejection fraction (LVEF) and cranial CT pathology.

Implications:

  • MIS-A requires a high index of suspicion in febrile patients with elevated inflammation and no clear alternative diagnosis.
  • Prompt treatment with corticosteroids and immunoglobulins may be vital for managing severe MIS-A, particularly to mitigate cardiac complications.

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