Ginger (Zingiber officinale) Root Extract During Pregnancy: A Clinical Feasibility Study

Area of Science:

• Pharmacology
• Obstetrics
• Gastroenterology

Background:

• Limited clinical data exists on concentrated ginger extracts during pregnancy.
• Ginger is commonly used for gastrointestinal discomfort, but safety in pregnancy requires investigation.

Purpose of the Study:

• To assess the feasibility and safety of a concentrated ginger extract (EXT.GR10) in pregnant women.
• To monitor maternal and newborn complications and evaluate patient satisfaction.

Main Methods:

• An observational clinical feasibility study involving 51 pregnant women.
• Participants could take up to 2 tablets (50mg EXT.GR10 each) daily for gastrointestinal issues.
• Maternal and neonatal outcomes were recorded, including malformations and complications.

Main Results:

• 44 out of 51 women used the ginger tablets.
• No serious maternal complications or stillbirths were reported.
• Four cases of hip dysplasia and two minor malformations were observed in newborns, with no clear link to ginger intake.

Conclusions:

• The concentrated ginger extract EXT.GR10 appears feasible for use in pregnancy.
• No direct relationship was found between EXT.GR10 dosage and adverse maternal or neonatal events.
• Further clinical trials are planned to confirm safety and efficacy, particularly during the first trimester.