[Related factors for bile duct infection after surgical treatment of biliary dilatation]

Objective: To analyze the related factors of bile duct infection in patients with biliary dilatation in the short and long term after operation. Methods: The data of the patients with biliary dilatation admitted at Peking Union Medical College Hospital between May 2012 and October 2020 were analyzed retrospectively. A total of 121 patients were enrolled in the study. There were 21 males(17.4%) and 100 females(82.6%),with age of (40.5±15.3) years(range: 18 to 80 years). Short-term infection was defined as bile duct infection occured within 30 days after operation; long-term infection was defined as bile duct infection occured 30 days after operation The relationship between bile duct infection and clinicopathologic biliary dilatation features were analyzed using univariate and multivariate analyses. Results: There were 85 (70.2%),1 (0.8%), 32 (26.4%) and 3 (2.5%) patients with Todani type Ⅰ,Ⅲ,Ⅳ and Ⅴ, respectively. The mean follow-up time was (55.2±28.6) months (range: 1 to 101 months). There were 18 and 37 patients had short-term and long-term bile duct infection after surgery,respectively. Postoperative complications occurred in 18 patients and included ascites(n=6),biliary fistula(n=4),pancreatic fistula(n=2),gastroparesis (n=2),pleural effusion(n=1),abdominal infection(n=1),non-healing wound(n=1),and pancreatitis(n=1). Univariate analysis showed that preoperative history of bile duct infection,hilar anastomosis and Todani types were related factors for short-term bile duct infection,and postoperative complication was a related factor for long-term bile duct infection. Multivariate analysis showed that hilar anastomosis(OR=6.228,95%CI: 1.884-20.586,P=0.003) and preoperative history of bile duct infection(OR=3.701,95%CI: 1.137-12.043,P=0.030) were independent related factors for short-term bile duct infection after biliary dilatation operation,and age ≥45 years (OR=2.261,95%CI:1.004-5.093,P=0.049) and postoperative complication (OR=3.131,95%CI:1.094-8.958,P=0.033) were independent related factors for long-term bile duct infection after biliary dilatation operation. Conclusion: Hilar anastomosis and preoperative history of bile duct infection are independent related factors for short-term bile duct infection after biliary dilatation operation,and ≥45 years old and postoperative complication are independent related factors for long-term bile duct infection after biliary dilatation operation.