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Related Experiment Videos

Electromechanical events during spontaneous angina.

G Ferro1, L Saccà, F Piscione

  • 1Department of Medicine, 2nd Medical School, University of Naples, Italy.

Cardiology
|January 1, 1988
PubMed
Summary

During acute myocardial ischemia, changes in heart rate and blood pressure significantly alter diastolic time, impacting coronary perfusion. Increased adrenergic tone worsens ischemia, while vagal tone may relieve angina by prolonging diastolic time.

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Area of Science:

  • Cardiology
  • Physiology

Background:

  • Acute myocardial ischemia can manifest with varying hemodynamic and electrocardiographic changes.
  • Understanding electromechanical events during ischemia is crucial for managing cardiac events.

Purpose of the Study:

  • To investigate the electromechanical events and their impact on diastolic time during spontaneous angina in patients undergoing cardiac catheterization.

Main Methods:

  • Recorded aortic pressure and electrocardiogram in 10 patients with spontaneous angina.
  • Measured heart rate and systolic/diastolic time intervals under control, angina, and pain relief conditions.

Main Results:

  • In 5 patients, angina increased heart rate and decreased diastolic time (48.8% to 33.6%), worsening ischemia.

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  • In 5 patients, angina decreased heart rate and increased diastolic time (39.4% to 47.8%), potentially aiding relief.

    • Conclusions:

    • Reflex adrenergic tone increase during ischemia may worsen myocardial perfusion by shortening diastolic time.
    • Vagal tone increase may contribute to angina relief by prolonging diastolic time, crucial for coronary perfusion.