Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Urinary System01:20

Disorders of the Urinary System

753
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
753
Nursing Assessment of the Genitourinary System I: Health History01:21

Nursing Assessment of the Genitourinary System I: Health History

200
The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
200
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

256
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
256
Urine Studies I: Urinalysis01:29

Urine Studies I: Urinalysis

568
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
568
Physiology of Urine Formation01:24

Physiology of Urine Formation

9.2K
Urine formation is an essential function of the human body. It plays a critical role in maintaining homeostasis by regulating the volume and composition of body fluids. The kidneys, the primary organs involved in this process, filter blood to remove waste products and excess substances, ultimately producing urine.
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
9.2K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

291
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
291

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A compact Kolmogorov-Arnold network mixer for long-term time series forecasting.

Scientific reports·2026
Same author

Comparison of personality domains derived from personality ratings and behavioral observations in Japanese macaques (Macaca fuscata).

Scientific reports·2026
Same author

Validation of the 2019 ACR/EULAR criteria for IgG4-related disease in a Japanese cardiovascular/retroperitoneal disease cohort: a multicentre retrospective study by the joint working group of the Japanese Circulation Society and the Ministry of Health, Labour and Welfare study group.

EULAR rheumatology open·2026
Same author

Structure-guided development of a potent human B<sup>0</sup>AT1 inhibitor effective in a mouse model of phenylketonuria.

Communications biology·2026
Same author

Iatrogenic immunodeficiency-associated polymorphic lymphoproliferative disorder resulting in complete remission after tacrolimus withdrawal in systemic lupus erythematosus: a case report.

Modern rheumatology case reports·2026
Same author

GPS: A Probabilistic Distributional Similarity with Gumbel Priors for Set-to-Set Matching.

... International Conference on Learning Representations·2026

Related Experiment Video

Updated: Nov 14, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.2K

Urinary abnormality in mixed connective tissue disease predicts development of other connective tissue diseases and

Ryo Nishioka1, Takeshi Zoshima1, Satoshi Hara1

  • 1Department of Rheumatology, Kanazawa University Hospital, Kanazawa, Japan.

Modern Rheumatology
|March 12, 2021
PubMed
Summary
This summary is machine-generated.

Urinary abnormality in patients with mixed connective tissue disease (MCTD) indicates a higher risk of developing other autoimmune diseases. This finding also suggests potential long-term kidney complications in MCTD patients.

Keywords:
Mixed connective tissue diseasedevelopment of other connective tissue diseaserenal involvementurinary abnormality

More Related Videos

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction
06:37

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

Published on: April 4, 2025

528
Assessing Urinary Tract Junction Obstruction Defects by Methylene Blue Dye Injection
06:05

Assessing Urinary Tract Junction Obstruction Defects by Methylene Blue Dye Injection

Published on: October 12, 2017

15.9K

Related Experiment Videos

Last Updated: Nov 14, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.2K
An Immature Murine Model of Reversible Unilateral Ureteral Obstruction
06:37

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

Published on: April 4, 2025

528
Assessing Urinary Tract Junction Obstruction Defects by Methylene Blue Dye Injection
06:05

Assessing Urinary Tract Junction Obstruction Defects by Methylene Blue Dye Injection

Published on: October 12, 2017

15.9K

Area of Science:

  • Rheumatology
  • Nephrology
  • Autoimmune Diseases

Background:

  • Mixed connective tissue disease (MCTD) is an autoimmune disorder with overlapping features of systemic lupus erythematosus, scleroderma, and polymyositis.
  • Urinary abnormalities, such as proteinuria and hematuria, can occur in MCTD patients, but their long-term clinical significance is not fully understood.

Purpose of the Study:

  • To investigate the clinical significance of developing urinary abnormality in patients diagnosed with MCTD.
  • To determine if urinary abnormality predicts the development of other connective tissue diseases (CTDs) or impacts long-term renal prognosis.

Main Methods:

  • Retrospective analysis of 41 patients initially diagnosed with MCTD, followed between 2000 and 2013.
  • Urinary abnormality defined as proteinuria and/or hematuria; development of other CTDs defined by established criteria.
  • Clinical parameters, including incidence of other CTDs and estimated glomerular filtration rate (eGFR) changes, were compared between patients with and without urinary abnormality.

Main Results:

  • Of 41 patients, 16 developed urinary abnormality (UrA(+)).
  • The incidence of developing other CTDs was significantly higher in UrA(+) patients (62.5%) compared to those without urinary abnormality (UrA(-)) (16.0%, p=0.01).
  • While follow-up duration and last eGFR did not differ, eGFR decreased more significantly in UrA(+) patients than UrA(-) patients (p=0.01 and p=0.03 for absolute and percentage change, respectively).

Conclusions:

  • Development of urinary abnormality during the course of MCTD is a predictor of a higher likelihood of developing other CTDs.
  • Urinary abnormality may also serve as an indicator for long-term renal prognosis in patients with an initial MCTD diagnosis.