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Related Experiment Videos

Somitogenesis in the mouse embryo.

D Ostrovsky1, J W Sanger, J W Lash

  • 1Department of Biology, Millersville University of Pennsylvania 17551.

Cell Differentiation
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

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Mouse somitogenesis involves fibronectin and cytoskeletal changes, similar to chick embryos. However, mouse somite formation differs as it lacks a closed epithelial vesicle stage before cell migration.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Embryology

Background:

  • Somitogenesis is a fundamental process in vertebrate embryonic development.
  • Understanding the molecular and cellular mechanisms driving somitogenesis is crucial for developmental biology.
  • Previous studies have characterized somitogenesis in various species, including the chick embryo.

Purpose of the Study:

  • To describe the initiation of somitogenesis in the mouse embryo.
  • To correlate fibronectin distribution with cytoskeletal element distribution during mouse somitogenesis.
  • To compare the process of somitogenesis in mice with that observed in chick embryos.

Main Methods:

  • Observation of fibronectin distribution around the unsegmented mesoderm.
  • Analysis of cytoskeletal element distribution within mesodermal cells.

Related Experiment Videos

  • Comparative analysis of somitogenesis stages between mouse and chick embryos.

    • Main Results:

    • Temporal and topological changes in fibronectin, laminin, and cytoskeletal elements during mouse somitogenesis mirror those in chick embryos.
    • A key difference observed is the absence of a closed epithelial vesicle stage in mouse somitogenesis.
    • In mice, the mesial portion of the forming somite does not become epithelial prior to sclerotomal cell migration.

    Conclusions:

    • Mouse somitogenesis shares conserved molecular and cellular features with chick somitogenesis, particularly regarding fibronectin and cytoskeletal dynamics.
    • The lack of a closed epithelial vesicle stage in mouse somitogenesis represents a significant divergence from the chick model.
    • These findings highlight species-specific variations in the epithelialization process during somite formation.