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Updated: Nov 14, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Pediatric Melanoma-Diagnosis, Management, and Anticipated Outcomes
Jennifer H Aldrink1, Stephanie F Polites2, Mary Austin3
1Division of Pediatric Surgery, Department of Surgery, Nationwide Children's Hospital, The Ohio State University College of Medicine, 700 Children's Drive, Faculty Office Building Suite 6B.1, Columbus, OH 43205, USA.
Abstract:
Melanoma is the most common skin cancer in children, often presenting in an atypical fashion. The incidence of melanoma in children has been declining. The mainstay of therapy is surgical resection. Sentinel lymph node biopsy often is indicated to guide therapy and determine prognosis. Completion lymph node dissection is recommended in selective cases after positive sentinel lymph node biopsy. Those with advanced disease receive adjuvant systemic treatment. Because children are excluded from melanoma clinical trials, management is based on pediatric retrospective data and adult clinical trials. This review focuses on epidemiology, presentation, surgical management, adjuvant therapy, and outcomes of pediatric melanoma.
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