Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Pineal Gland01:02

The Pineal Gland

3.4K
The pineal gland, a diminutive endocrine structure named for its pinecone-shaped appearance, is situated atop the third ventricle within the diencephalon region of the forebrain. This gland, composed of secretory cells known as pinealocytes arranged in compact cords and clusters around dense particles of calcium salts, plays a pivotal role in hormonal regulation.
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
3.4K
Management of Insomnia01:19

Management of Insomnia

381
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
381
Aging01:26

Aging

415
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
415
Understanding Sleep01:11

Understanding Sleep

1.1K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.1K
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

1.2K
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
1.2K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chronobiotic and cytoprotective activity of melatonin in the cardiovascular system. Doses matter.

Npj biological timing and sleep·2026
Same author

Rethinking Melatonin Dosing: Safety and Efficacy at Higher-than-Usual Levels in Aged Patients with Sleep Disturbances and Comorbidities.

Brain sciences·2025
Same author

Efficacy of a Neuroimmune Therapy Including Pineal Methoxyindoles, Angiotensin 1-7, and Endocannabinoids in Cancer, Autoimmune, and Neurodegenerative Diseases.

Clinical interventions in aging·2025
Same author

Function of intramitochondrial melatonin and its association with Warburg metabolism.

Cellular signalling·2025
Same author

Melatonin stabilizes atherosclerotic plaques: an association that should be clinically exploited.

Frontiers in medicine·2024
Same author

Melatonin as a Chronobiotic and Cytoprotector in Non-communicable Diseases: More than an Antioxidant.

Sub-cellular biochemistry·2024
Same journal

Bilateral macronodular and micronodular hyperplasia: Biochemical, radiological and genetic diagnosis.

Vitamins and hormones·2026
Same journal

ACTH independent Cushing's syndrome: Diagnosis and etiology.

Vitamins and hormones·2026
Same journal

Biochemical diagnosis of hypercortisolism: When and how?

Vitamins and hormones·2026
Same journal

New tools for the diagnosis of hypercortisolism.

Vitamins and hormones·2026
Same journal

Cardiometabolic comorbidities in overt Cushing's syndrome.

Vitamins and hormones·2026
Same journal

Molecular profile of Cushing's syndrome.

Vitamins and hormones·2026
See all related articles

Related Experiment Video

Updated: Nov 14, 2025

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

2.8K

Melatonin and healthy aging.

Daniel P Cardinali1

  • 1Faculty of Medical Sciences, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina.

Vitamins and Hormones
|March 12, 2021
PubMed
Summary
This summary is machine-generated.

Healthy aging relies on circadian rhythms, nutrition, and exercise. Melatonin, a key hormone, declines with age, impacting sleep and increasing inflammation, but supplementation may offer therapeutic benefits for aging and related diseases.

Keywords:
AgingAlzheimer's diseaseCircadian clockCytoprotectionGlymphatic flowInflammagingMelatoninMetabolic syndromeOxidative stressSleep

More Related Videos

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
12:02

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Published on: July 30, 2016

16.2K
A Simple and Efficient Method for In Vivo Cardiac-specific Gene Manipulation by Intramyocardial Injection in Mice
06:42

A Simple and Efficient Method for In Vivo Cardiac-specific Gene Manipulation by Intramyocardial Injection in Mice

Published on: April 16, 2018

16.5K

Related Experiment Videos

Last Updated: Nov 14, 2025

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

2.8K
Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
12:02

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Published on: July 30, 2016

16.2K
A Simple and Efficient Method for In Vivo Cardiac-specific Gene Manipulation by Intramyocardial Injection in Mice
06:42

A Simple and Efficient Method for In Vivo Cardiac-specific Gene Manipulation by Intramyocardial Injection in Mice

Published on: April 16, 2018

16.5K

Area of Science:

  • Gerontology
  • Chronobiology
  • Endocrinology

Background:

  • Aging is associated with circadian rhythm disruption, including sleep disturbances and inflammation, leading to metabolic disorders and accelerated aging.
  • Sleep disruption impairs central nervous system functions, such as waste molecule clearance.
  • Decreased plasma melatonin levels are linked to aging and various age-related diseases, including cardiovascular and neurodegenerative disorders.

Purpose of the Study:

  • To explore the role of melatonin in healthy aging and its potential therapeutic applications.
  • To investigate melatonin's chronobiotic and cytoprotective effects in the context of aging.
  • To highlight the need for further research into optimal melatonin dosages for therapeutic benefits.

Main Methods:

  • Review of existing literature on circadian rhythms, aging, and melatonin.
  • Analysis of melatonin's effects on circadian pacemakers and cellular functions.
  • Examination of clinical trial data and animal studies on melatonin supplementation.

Main Results:

  • Melatonin synchronizes circadian clocks and possesses cytoprotective properties, including antioxidant and anti-inflammatory actions.
  • Melatonin administration in aged animals counteracts senescence-related changes.
  • Reduced circulating melatonin levels are observed in metabolic syndrome, cardiovascular diseases, and neurodegenerative disorders.

Conclusions:

  • Melatonin acts as both a chronobiotic and cytoprotective agent, crucial for maintaining healthy aging.
  • Melatonin holds potential therapeutic value for age-related conditions, but higher doses may be required for cytoprotective effects.
  • Controlled studies using higher melatonin doses (e.g., 100mg/day) are necessary to fully elucidate its therapeutic potential in aging.