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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Luteinizing hormone and the aging brain.

Megan Mey1, Sabina Bhatta1, Gemma Casadesus2

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|March 12, 2021
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Summary
This summary is machine-generated.

Luteinizing hormone (LH) impacts brain function and cognition, especially during aging and Alzheimer's disease (AD). This review explores LH's CNS roles and proposes a unifying hypothesis for its signaling in brain aging and disease.

Keywords:
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Area of Science:

  • Neuroendocrinology
  • Aging Research
  • Neurodegenerative Diseases

Background:

  • Luteinizing hormone (LH) release fluctuates and is crucial for reproductive health, but also impacts the central nervous system (CNS).
  • Extra-gonadal roles of LH in CNS function, cognition, and plasticity are increasingly recognized, particularly in aging and Alzheimer's disease (AD).
  • Current understanding of LH mechanisms in the brain and their influence on cognition throughout the lifespan is limited and contains conflicting theories.

Purpose of the Study:

  • To provide an updated review of the literature on LH signaling in CNS aging and disease.
  • To explore the mechanisms of LH action within the brain.
  • To propose a unifying hypothesis for LH signaling in CNS function and dysfunction during aging and disease.

Main Methods:

  • Literature review of existing studies on LH, CNS function, aging, and neurodegenerative diseases.
  • Analysis of evidence for extra-gonadal roles of LH in the brain.
  • Synthesis of conflicting theories regarding LH signaling in the CNS.

Main Results:

  • Evidence suggests LH plays a significant role in CNS plasticity and cognition, independent of its reproductive functions.
  • LH signaling pathways in the brain are complex and not fully elucidated.
  • Conflicting findings in the literature may stem from variations in experimental models, age groups, and specific signaling pathways studied.

Conclusions:

  • LH is a key neuroendocrine regulator with significant implications for cognitive function and brain health across the lifespan.
  • Further research is needed to clarify the precise mechanisms of LH action in the CNS and its role in aging and AD.
  • A unifying hypothesis is proposed to reconcile existing theories and guide future investigations into LH's role in brain aging and disease.