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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone Structure01:55

Bone Structure

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Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
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The Bone Matrix01:18

The Bone Matrix

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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What is the Skeletal System?01:02

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Overview
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The Functions of the Skeletal System01:22

The Functions of the Skeletal System

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The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
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Updated: Nov 14, 2025

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
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Adynamic bone disease: Revisited.

Sonia Sharma1, Ankur Gupta2

  • 1Pediatric Nephrology, Max Superspeciality Hospital, Shalimar Bagh, New Delhi, India.

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|March 12, 2021
PubMed
Summary
This summary is machine-generated.

Adynamic bone disease (ABD) is a growing concern in chronic kidney disease-mineral bone disorder (CKD-MBD) management. This review covers updated insights into its causes, risk factors, and treatment strategies for CKD patients.

Keywords:
Adynamic bone diseaseBiopsia óseaBone biopsyCKD-MBDERC-TMOEnfermedad ósea adinámica

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Area of Science:

  • Nephrology
  • Endocrinology
  • Bone Metabolism

Background:

  • Bone and mineral disorders are crucial in managing chronic kidney disease (CKD).
  • Chronic kidney disease-mineral bone disorder (CKD-MBD) encompasses various bone pathologies.
  • Adynamic bone disease (ABD) is increasingly prevalent within CKD-MBD.

Purpose of the Study:

  • To provide an updated review of adynamic bone disease (ABD) in chronic kidney disease (CKD).
  • To discuss the current understanding of ABD pathophysiology.
  • To outline current risk factors and management strategies for ABD.

Main Methods:

  • Literature review of recent studies on adynamic bone disease.
  • Synthesis of information on pathophysiology, risk factors, and management.
  • Focus on updated clinical insights and research findings.

Main Results:

  • Adynamic bone disease (ABD) prevalence is rising in CKD patients.
  • Pathophysiology involves complex interactions affecting bone turnover.
  • Multiple risk factors contribute to ABD development and progression.

Conclusions:

  • Effective management of CKD-MBD requires attention to increasing ABD prevalence.
  • Updated knowledge of pathophysiology and risk factors is essential for targeted interventions.
  • Current management strategies aim to mitigate ABD progression and its complications.