Association of sleep disorders with subfoveal choroidal thickness in preschool children
Shiya Shen1, Xiaoxiao Li1, Rui Li1
1Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Insights
Daytime sleepiness in preschool children is linked to thinner subfoveal choroid (SFCT). This study highlights a potential connection between sleep disorders and ocular development in children.
Area of Science:
- Ophthalmology
- Pediatrics
- Sleep Medicine
Background:
- Subfoveal choroidal thickness (SFCT) is a key indicator of ocular health.
- Sleep disorders are increasingly recognized as potential factors influencing child development.
Purpose of the Study:
- To investigate the association between sleep disorders and SFCT in preschool-aged children.
- To identify specific sleep-related factors impacting choroidal thickness.
Main Methods:
- A population-based cross-sectional study included 1337 children aged 60-72 months.
- Subfoveal choroidal thickness was measured using spectral-domain optical coherence tomography (SD-OCT).
- Sleep disorders were assessed using the Chinese version of the Children's Sleep Habits Questionnaire (CSHQ), with multiple linear regression analyses performed.
Main Results:
- Higher overall CSHQ scores (indicating more sleep disorders) were associated with thinner SFCT (P=0.046).
- Daytime sleepiness, a specific CSHQ subscale, showed a significant negative association with SFCT (P=0.001).
- Children with clinically significant daytime sleepiness had markedly thinner SFCT compared to their peers (295.47 vs. 308.52 μm, P=0.007).
Conclusions:
- Daytime sleepiness emerged as the primary sleep-related factor associated with reduced SFCT in preschool children.
- Further research is warranted to elucidate the relationship between childhood sleep disorders and ocular development.
Objective:
To explore the association between sleep disorders and subfoveal choroidal thickness (SFCT) in preschool children.
Methods:
In this population-based cross-sectional study, children aged 60-72 months were measured for SFCT using spectral-domain optical coherence tomography (SD-OCT) and for sleep disorders using the Chinese version of Children's Sleep Habits Questionnaire (CSHQ). Multiple linear regression analyses were performed to assess the association between sleep disorders and SFCT.
Results:
A total of 1337 children (mean (SD) age: 66.88 (3.41) months) were included in the analyses. In multivariable linear analysis, a higher total CSHQ score (indicating higher likelihood of sleep disorders) was associated with a thinner subfoveal choroid (beta, -0.070; 95% CI, -0.141 to -0.001; P = 0.046). When each of eight CSHQ subscale scores was analysed by the multivariable model, only the Daytime Sleepiness subscale score was negatively associated with the SFCT (beta, -0.115; 95% CI, -0.183 to -0.046; P = 0.001). The children with clinically significant daytime sleepiness (n = 364, 27.2%) had significantly thinner subfoveal choroid than other children (295.47 vs. 308.52 μm, P = 0.007).
Conclusions:
Only daytime sleepiness was significantly associated with SFCT in preschool children in this study. The potential relationship between sleep disorders during childhood and children's ocular development needs further research.
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