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The EXCEL Trial: The Interventionalists' Perspective
George William Hunter1, Vinoda Sharma1, Chetan Varma1
1Department of Cardiology, Sandwell and West Birmingham Hospitals NHS Trust Birmingham, UK.
European Cardiology
|March 12, 2021
Summary
Left main stem (LMS) disease management has evolved with percutaneous coronary intervention (PCI) advancements. Current literature and trials like EXCEL inform updated treatment strategies for this critical coronary artery subset.
Area of Science:
- Cardiology
- Interventional Cardiology
- Clinical Trials
Background:
- Left main stem (LMS) disease affects up to 5% of diagnostic angiography cases, posing significant morbidity and mortality risks.
- Historically, surgical intervention was standard, but percutaneous coronary intervention (PCI) has gained prominence.
- Recent European and International guidelines reflect evolving management strategies for LMS disease.
Purpose of the Study:
- To provide an overview of current literature on managing LMS disease with PCI.
- To discuss new developments and emerging concepts in PCI for LMS lesions.
- To analyze the impact of recent trials, such as the EXCEL trial, on clinical practice.
Main Methods:
- Review of current literature on LMS disease management.
- Analysis of percutaneous coronary intervention (PCI) strategies and technologies.
- Examination of data from key clinical trials, including the EXCEL trial.
Main Results:
- PCI strategies for LMS disease have significantly evolved over the past decade.
- New evidence and technological advancements are reshaping treatment paradigms.
- Recent trials provide critical data influencing updated clinical guidance.
Conclusions:
- PCI is an increasingly viable and evidence-based option for select LMS disease patients.
- Ongoing research and technological innovation continue to refine PCI approaches for LMS disease.
- Updated guidelines reflect the growing role of PCI in LMS disease management.
Keywords:
EXCELLeft main stemMIcoronary artery bypass graftingmajor adverse cardiovascular eventspercutaneous coronary interventiontarget lesion revascularisationMore Related Videos
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