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Updated: Nov 14, 2025

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
Conventional cardiac surgery in patients with end-stage coronary artery disease: yesterday and today
Michal Szlapka1, Roland Hetzer2, Jürgen Ennker3
1Department of Cardiac and Vascular Surgery, MediClin Heart Center Coswig, Coswig, Germany.
Insights
Surgical options for end-stage coronary artery disease (CAD) and heart failure include bypass grafting, ventricle restoration, and transplantation. Coronary artery bypass grafting (CABG) is a key alternative when donors are scarce.
Area of Science:
- Cardiovascular Surgery
- Heart Failure Management
- Coronary Artery Disease Treatment
Background:
- End-stage coronary artery disease (CAD) often presents with heart failure, necessitating complex surgical interventions.
- Traditional surgical approaches have evolved, offering a range of options beyond heart transplantation.
Purpose of the Study:
- To provide an overview of current and evolving surgical practices for patients with end-stage CAD.
- To highlight the role of coronary artery bypass grafting (CABG) and other surgical techniques.
Main Methods:
- Review of contemporary surgical strategies for combined CAD and heart failure.
- Discussion of coronary artery bypass grafting (CABG), surgical ventricle restoration (SVR), and mechanical circulatory support (MCS).
Main Results:
- Coronary artery bypass grafting (CABG), with or without surgical ventricle restoration (SVR), remains a significant surgical option.
- CABG serves as a viable alternative to heart transplantation due to donor limitations.
- Mechanical circulatory support (MCS) offers salvage and reevaluation opportunities for non-surgical candidates.
Conclusions:
- Surgical management of end-stage CAD is multifaceted, encompassing revascularization, restoration, transplantation, and mechanical support.
- The choice of surgical therapy depends on patient selection, myocardial viability, and donor availability.
Abstract:
Surgical therapy of combined coronary artery disease (CAD) and heart failure, also referred to as end-stage CAD, has evolved throughout the years and patients are currently being offered traditional coronary artery bypass grafting (CABG), with or without surgical ventricle restoration (SVR), interventions for ischemic mitral valve regurgitation, heart transplantation or implantation of mechanical cardiovascular support systems. Among surgical methods, operative myocardial revascularization (with or without ventricle restoration) is still playing an important role, aiming at restoration of proper myocardial perfusion, especially if heart muscle viability is present. Facing the donor shortage, CABG may constitute a valuable alternative to transplantation in selected patients. In individuals considered not suitable for surgical revascularization, implantation of mechanical circulatory support (MCS) not only appears as a salvage procedure, but also allows for reevaluation of future therapy directions. This article aims at providing an overview of evolving and current surgical practices in patients with end-stage CAD.
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