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The effects of menthol isomers on nasal sensation of airflow
R Eccles1, D H Griffiths, C G Newton
1Department of Physiology, University College, Cardiff.
Clinical Otolaryngology and Allied Sciences
|February 1, 1988
Abstract:
The effects of inhalation of L-menthol, D-isomenthol and D-neomenthol, upon nasal resistance and sensation to airflow were investigated in 40 subjects. L-menthol caused a highly significant enhancement of nasal sensation of airflow but despite their great similarity in structure and a similar peppermint smell the isomers D-isomenthol and D-neomenthol had no effect on nasal sensation of airflow. These findings show that L-menthol has a specific pharmacological action on nasal sensory nerve endings which is not related to its peppermint smell.