Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Nov 13, 2025

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

12.7K

Comparative Study on Different Skin Pruritus Mouse Models.

Guan Donglang1, Liu Tongtong1, Chen Dan1

  • 1School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

Frontiers in Medicine
|March 12, 2021
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Zonated mechanosensing by PIEZO1 controls liver regeneration.

Science (New York, N.Y.)·2026
Same author

Orientin inhibits cyclin E/cyclin A-CDK2 to induce growth arrest at senescence in human gastric cancer cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
Same author

Early Outcomes of Real-World Aortic Valve Replacement With RESILIA Tissue in the Chinese Population.

Clinical cardiology·2026
Same author

Comparative modelling of two migratory locusts along the China-Kazakhstan border under climate change: Poleward habitat shifts and increasing transboundary risk.

Pest management science·2026
Same author

Nanomedicine carrier-based combined antitumor strategy integrating phototherapy and immunotherapy.

Immunopharmacology and immunotoxicology·2026
Same author

Ligation site of the inferior mesenteric vein in laparoscopic radical resection of rectal cancer: a study protocol for a multicenter randomized-controlled trial.

Gastroenterology report·2026
Same journal

Family cohesion and adaptability in heart failure: an APIMeM analysis of symptom perception and spousal caregiving on patient self-care.

Frontiers in medicine·2026
Same journal

Prognostic factors analysis of surgical resection after conversion therapy for isolated pleural metastatic lung cancer: a retrospective analysis.

Frontiers in medicine·2026
Same journal

Case Report: a novel non-canonical splice site variant in COL4A5 in a patient with Alport syndrome.

Frontiers in medicine·2026
Same journal

Minimally invasive percutaneous cannulated screw fixation for pelvic fractures: a retrospective case cohort study of clinical and radiological outcomes.

Frontiers in medicine·2026
Same journal

A case analysis of Gitelman syndrome complicated with Sjögren's disease.

Frontiers in medicine·2026
Same journal

Inflammatory phenotyping by latent class analysis and machine learning-based prediction of postoperative complications in pediatric appendicitis: a retrospective cohort study.

Frontiers in medicine·2026
See all related articles

Researchers compared four animal models for studying itch (pruritus). The urushiol-induced model demonstrated rapid, stable scratching behavior and significant skin changes, making it ideal for developing anti-itch drugs.

Area of Science:

  • Dermatology
  • Toxicology
  • Immunology

Background:

  • Animal models are crucial for understanding disease mechanisms, including pruritus (itch).
  • Scratching behavior is a primary indicator in pruritus research, necessitating models with rapid and stable induction.
  • Existing models vary in their ability to consistently elicit and maintain scratching responses.

Purpose of the Study:

  • To compare the efficacy of four different substances in inducing animal models of pruritus.
  • To identify an optimal animal model for studying itch mechanisms and evaluating antipruritic agents.
  • To assess the speed, stability, and biological changes associated with different pruritus models.

Main Methods:

  • Comparison of pruritus induction in mice using four distinct chemical agents: urushiol, 2,4-dinitrofluorobenzene, oxazolone, and imiquimod.
Keywords:
allergic contact dermatitisanimal modelatopic dermatitisprurituspsoriasisurushiol

More Related Videos

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

4.3K
Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

9.9K

Related Experiment Videos

Last Updated: Nov 13, 2025

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

12.7K
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

4.3K
Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

9.9K
  • Evaluation of scratching behavior onset, plateau, and stability.
  • Assessment of histopathological changes, including epidermal thickening and inflammatory cell infiltration.

    • Main Results:

    • Urushiol effectively induced scratching behavior that reached a plateau phase more rapidly and exhibited greater stability compared to the other three agents.
    • The urushiol model showed more pronounced epidermal thickening and inflammatory cell aggregation.
    • Urushiol-induced pruritus is a globally relevant condition, particularly in regions like the US and Europe, affecting outdoor workers.

    Conclusions:

    • The urushiol-induced animal model is a superior choice for studying the mechanisms of itch formation due to its rapid and stable induction of scratching behavior.
    • This model provides significant histopathological changes relevant to pruritic conditions.
    • The urushiol model holds promise for the development and testing of novel antipruritic drugs.