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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
Published on: November 10, 2023
Risk factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections: a nationwide
Seon Cheol Park1, Sun Young Won1, Na Hye Kim1
1Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Republic of Korea.
Insights
Women, individuals in COVID-19 outbreak areas, Medical Aid beneficiaries, and those with diabetes mellitus face higher risks of SARS-CoV-2 infection. These findings highlight key demographics for targeted public health interventions.
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- The COVID-19 pandemic poses a global health emergency.
- Risk factors for SARS-CoV-2 infection require further elucidation.
- This study focuses on identifying clinical risk factors in Korea amidst public health recommendations.
Purpose of the Study:
- To identify clinical risk factors associated with SARS-CoV-2 infection.
- To analyze risk factors in the Korean population during the early stages of the pandemic.
- To inform public health strategies for infection control.
Main Methods:
- Utilized data from the Health Insurance Review and Assessment Service dataset.
- Included individuals tested for SARS-CoV-2 via RT-PCR between January 3 and May 31, 2020.
- Employed multivariable logistic regression models to determine risk factors.
Main Results:
- Analysis of 219,729 tests revealed 7,333 positive cases.
- Female sex, living in high-outbreak areas, and Medical Aid beneficiary status increased SARS-CoV-2 risk.
- Diabetes mellitus was also associated with a higher likelihood of positive test results.
Conclusions:
- Certain demographics, including women, individuals in outbreak zones, Medical Aid beneficiaries, and those with diabetes, exhibit elevated SARS-CoV-2 infection risk.
- These groups may require specific attention for prevention strategies.
- Findings underscore the need for continued risk factor research in infectious disease outbreaks.
Background:
The coronavirus disease 2019 (COVID-19) has rapidly turned into a public health emergency worldwide; however, the risk factors for infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been well-described. We aimed to identify the clinical risk factors for SARS-CoV-2 infections in Korea, where social distancing and face masks have been strongly recommended.
Methods:
The data of individuals who underwent the reverse transcription polymerase chain reaction test for SARS-CoV-2 between January 3 and May 31, 2020 were retrieved from the Health Insurance Review and Assessment Service dataset. We used multivariable logistic regression models to identify the risk factors for SARS-CoV-2 infections in the population.
Results:
We retrieved the results of 219,729 SARS-CoV-2 tests, of which 7,333 were positive results. In the multivariable analysis, female sex was associated with a higher risk of testing positive for SARS-CoV-2 [odds ratio (OR) =1.30, 95% confidence interval (CI): 1.24-1.37, P<0.0001]. Additionally, populations living in areas that had large outbreaks of COVID-19 were at an increased risk of testing positive for SARS-CoV-2 (OR =6.87, 95% CI: 6.55-7.21, P<0.0001). The odds of a positive test were greater for the Medical Aid beneficiaries (OR =1.99, 95% CI: 1.82-2.18, P<0.0001) than for the National Health Insurance beneficiaries. Individuals with diabetes mellitus (DM) were more likely to test positive (OR =1.15, 95% CI: 1.07-1.24, P=0.0002).
Conclusions:
Women, individuals living in areas with large outbreaks of COVID-19, Medical Aid beneficiaries, and individuals with DM might have greater risks of contracting SARS-CoV-2 infections despite practicing social distancing and using face masks.
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