Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patterns of Colorectal Cancer Diagnosis in Older Adults: A SEER-Medicare Analysis of Health and Economic Impact of Missed Screening Opportunities.

Journal of surgical oncology·2026
Same author

The Unfinished Journey After Major Surgery: Interhospital Transfer and Care Fragmentation.

World journal of surgery·2026
Same author

Hepatocellular carcinoma: new therapies on the horizon.

Expert review of gastroenterology & hepatology·2026
Same author

Sexual orientation and gender identity based disparities in colorectal, cervical, and breast cancer screening in the United States.

Cancer·2026
Same author

A novel classification of small bowel adenocarcinoma based on the hidden genome classifier: a multi-institutional study.

Journal of the National Cancer Institute·2026
Same author

A Tale of Two Pathways: Same-Surgeon Versus Different-Surgeon Resection After Second Surgical Opinion.

Journal of surgical oncology·2026

Related Experiment Video

Updated: Nov 13, 2025

The Influence of Liver Resection on Intrahepatic Tumor Growth
07:55

The Influence of Liver Resection on Intrahepatic Tumor Growth

Published on: April 9, 2016

9.7K

Defining the Risk of Early Recurrence Following Curative-Intent Resection for Distal Cholangiocarcinoma.

Kota Sahara1,2, Diamantis I Tsilimigras2, Junya Toyoda1

  • 1Department of Gastroenterological Surgery, Yokohama City University School of Medicine, Yokohama, Japan.

Annals of Surgical Oncology
|March 12, 2021
PubMed
Summary

Nearly 30% of distal cholangiocarcinoma patients experience early recurrence after surgery. A new risk score identifies high-risk individuals, aiding treatment decisions for this challenging biliary tract cancer.

More Related Videos

Laparoscopic Left Hemihepatectomy Combined with Caudate Lobe Resection
07:22

Laparoscopic Left Hemihepatectomy Combined with Caudate Lobe Resection

Published on: April 11, 2025

490
Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb
04:50

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb

Published on: January 17, 2025

512

Related Experiment Videos

Last Updated: Nov 13, 2025

The Influence of Liver Resection on Intrahepatic Tumor Growth
07:55

The Influence of Liver Resection on Intrahepatic Tumor Growth

Published on: April 9, 2016

9.7K
Laparoscopic Left Hemihepatectomy Combined with Caudate Lobe Resection
07:22

Laparoscopic Left Hemihepatectomy Combined with Caudate Lobe Resection

Published on: April 11, 2025

490
Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb
04:50

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb

Published on: January 17, 2025

512

Area of Science:

  • Oncology
  • Surgical Oncology
  • Gastroenterology

Background:

  • Distal cholangiocarcinoma (DCC) patients face recurrence risks despite multidisciplinary treatments and adjuvant therapy (AT).
  • Early recurrence (ER) within 12 months post-surgery remains a significant concern for DCC.
  • Characterizing ER incidence and predictors is crucial for improving patient outcomes.

Purpose of the Study:

  • To determine the incidence of early recurrence (ER) in patients who underwent surgery for distal cholangiocarcinoma (DCC).
  • To identify clinicopathological predictors associated with a higher risk of ER after DCC resection.
  • To develop and validate a predictive risk score for ER in DCC patients.

Main Methods:

  • Analysis of a US multi-institutional database of 245 patients who underwent DCC resection (2000-2015).
  • Cox regression analysis to identify factors predicting ER and develop an ER risk score.
  • Validation of the predictive model in an external dataset.

Main Results:

  • 27.3% of patients experienced ER; adjuvant therapy (AT) showed no significant impact on ER rates.
  • Key predictors for higher ER risk included neutrophil-to-lymphocyte ratio (NLR), peak total bilirubin (T-Bil), major vascular resection (MVR), lymphovascular invasion, and R1 surgical margin.
  • A DIstal Cholangiocarcinoma Early Recurrence Score (DCCERS) was developed, showing significantly increased ER rates with higher scores (10.6% low risk to 57.6% high risk).

Conclusions:

  • Approximately one in four patients with DCC experience early recurrence post-resection.
  • The developed DCCERS effectively stratifies patients into low, intermediate, and high-risk groups for ER.
  • Consideration of alternative strategies like neoadjuvant chemotherapy is recommended for high-risk DCC patients.