Immunologic Control of HIV-1: What Have We Learned and Can We Induce It?

A large amount of data now exists on the virus-specific immune response associated with spontaneous or induced immunologic control of lentiviruses. This review focuses on how the current understanding of HIV-specific immunity might be leveraged into induction of immunologic control and what further research is needed to accomplish this goal.

During chronic infection, the function most robustly associated with immunologic control of HIV-1 is CD8⁺ T cell cytotoxic capacity. This function has proven difficult to restore in HIV-specific CD8⁺ T cells of chronically infected progressors in vitro and in vivo. However, progress has been made in inducing an effective CD8⁺ T cell response prior to lentiviral infection in the macaque model and during acute lentiviral infection in non-human primates. Further study will likely accelerate the ability to induce an effective CD8⁺ T cell response as part of prophylactic or therapeutic strategies.