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Related Experiment Video

Updated: Nov 13, 2025

Efficient Method for Imaging Murine Lungs that Preserves Spatial Dynamics of Fungal Spores in the Airways

Efficient Method for Imaging Murine Lungs that Preserves Spatial Dynamics of Fungal Spores in the Airways

Published on: December 13, 2024

Respiratory Mycoses in COPD and Bronchiectasis.

Pei Yee Tiew^1,2, Micheál Mac Aogáin^3,4, Soo Kai Ter¹

¹Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Nanyang, 308232, Singapore.

|March 12, 2021

Summary

Fungi play a significant role in chronic obstructive pulmonary disease (COPD) and bronchiectasis exacerbations. Understanding airway mycobiomes improves diagnosis and treatment for these chronic airway diseases.

Keywords:

Aspergillus Fungi ITS sequencing Mycobiome Respiratory mycoses

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Last Updated: Nov 13, 2025

Efficient Method for Imaging Murine Lungs that Preserves Spatial Dynamics of Fungal Spores in the Airways

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Published on: December 13, 2024

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The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections

Published on: May 8, 2017

Area of Science:

Pulmonology and Medical Mycology

Background:

Chronic obstructive pulmonary disease (COPD) and bronchiectasis are major causes of illness and death.
Fungal roles in exacerbations of these chronic airway diseases are not well understood.
Aspergillus species are linked to COPD and bronchiectasis, but progression from colonization to invasive disease is unclear.

Purpose of the Study:

To review the clinical significance of fungi in COPD and bronchiectasis.
To discuss diagnostic methods and mycobiome sequencing for airway fungi.
To explore associations between airway fungi and clinical outcomes.

Main Methods:

Review of emerging evidence on fungal infections in chronic airway diseases.
Analysis of diagnostic modalities for fungal detection.
Examination of mycobiome sequencing data and its clinical correlations.

Main Results:

Advances in molecular technology enhance the detection and identification of airway fungi.
Mycobiome sequencing reveals diverse fungal profiles in COPD and bronchiectasis.
Fungal presence is associated with disease presentation, progression, and mortality.

Conclusions:

Fungi are clinically important in COPD and bronchiectasis.
Mycobiome analysis offers insights into disease mechanisms and outcomes.
Further research is needed to clarify fungal roles and optimize management strategies.