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Large-scale resolution of gossypol enantiomers for biological evaluation
S A Matlin1, R H Zhou, A Belenguer
1Chemistry Department, The City University, London, UK.
Contraception
|March 1, 1988
Abstract:
Gossypol has been resolved into its pure optical isomers by conversion into the Schiff's base derivative of (+)-phenylalanine methyl ester, normal or reverse phase chromatography and hydrolysis. Forty grams of pure (-)-gossypol has been prepared in a micronised form for assessment of its antifertility and toxicological effects.