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Updated: Nov 13, 2025

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
Published on: July 17, 2016
Kidney injury biomarkers during exposure to tenofovir-based preexposure prophylaxis
Thomas L Nickolas1, Jonathan Barasch1, Kenneth K Mugwanya2
1Department of Medicine, Columbia Irving University Medical Center, New York, NY.
Abstract:
We previously reported a higher incidence of non-albumin proteinuria and a small but significant decline in estimated glomerular filtration rate (eGFR) among HIV-negative adults randomized to emtricitabine/tenofovir disoproxil fumarate preexposure prophylaxis (FTC/TDF PrEP) versus placebo. In a nested case--control study among participants randomized to FTC/TDF PrEP, established kidney injury biomarkers measured at 12 months were not significantly different between participants who subsequently experienced one of these kidney endpoints and randomly selected controls who did not.
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