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Updated: Nov 13, 2025
Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
Published on: May 10, 2021
Clinical Outcomes of Patients With pT1-T2N0 Oral Tongue Squamous Cell Carcinoma
Jessica M Wilson1, Catherine Lumley2, Xianming Tan3
1Department of Radiation Oncology, University of North Carolina Hospitals.
Objective:
The objective of this study was to evaluate the clinical outcomes in a cohort of patients with early-stage oral tongue squamous cell carcinoma (OTSCC).
Materials And Methods:
We conducted a retrospective analysis of patients with pT1-T2N0 (American Joint Committee on Cancer [AJCC] seventh edition) OTSCC treated from 2000 to 2018. Two-year actuarial rates of local regional control, cancer-specific survival, and overall survival were calculated for the entire cohort and patients with/without adjuvant radiation.
Results:
Ninety-six patients met the criteria with a median follow-up of 4 years; 14 had adjuvant radiation, while 82 had surgery alone. Two-year local regional control was 82.7% (75.4% to 90.8%) for the entire cohort, 84.9% (77.8% to 93.2%) for surgery only, and 70.7% (50.2% to 99.6%) for patients with adjuvant radiation. Two-year progression-free survival was 82.7% (75.3% to 90.8%). Of the 20 patients with recurrence, 11 (55%) were successfully salvaged.
Conclusion:
Local regional recurrence remains modest in early-stage OTSCC, but salvage is possible with high survival rates.
Level Of Evidence:
Level III-retrospective cohort study.
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