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Related Experiment Video

Updated: Nov 13, 2025

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A review on acoustic droplet ejection technology and system.

Qing Guo1, Xiao Su, Xingguo Zhang

  • 1State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin 300072, China. dchli@tju.edu.cn.

Soft Matter
|March 12, 2021
PubMed
Summary

Acoustic droplet ejection (ADE) offers precise, reproducible, and cost-effective liquid handling for biological research, replacing traditional methods. This review details ADE technology, its components, and future potential in fields like synthetic biology and personalized medicine.

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Area of Science:

  • Chemical and biological research
  • Biotechnology
  • Analytical chemistry

Background:

  • Advancements in detection systems necessitate improved liquid handling and sample preparation.
  • Traditional liquid handling robots face limitations in precision, cost, and waste generation.
  • Acoustic droplet ejection (ADE) offers a novel solution to these challenges.

Purpose of the Study:

  • To provide a comprehensive review of acoustic droplet ejection (ADE) technology.
  • To detail the critical components and underlying technologies of ADE systems.
  • To discuss the advantages, disadvantages, and future prospects of ADE.

Main Methods:

  • Review of existing literature and technologies related to ADE.
  • Detailed explanation of ADE system setup, including droplet generation, fluid well design, droplet coalescence, and power control.
  • Analysis of the benefits and drawbacks of current ADE technologies.

Main Results:

  • ADE enhances precision and data reproducibility in liquid handling.
  • ADE reduces costs, hands-on time, and eliminates waste compared to traditional methods.
  • ADE is increasingly adopted in synthetic biology, genotyping, personalized medicine, and next-generation sequencing.

Conclusions:

  • Acoustic droplet ejection technology is a transformative approach to liquid handling in life sciences.
  • Understanding ADE's core technologies is crucial for its optimization and advancement.
  • ADE is poised for significant future development and broader application in research and diagnostics.