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Towards Biomimicking Wood: Fabricated Free-standing Films of Nanocellulose, Lignin, and a Synthetic Polycation

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Structure evolution during phase separation in spin-coated ethylcellulose/hydroxypropylcellulose films.

Pierre Carmona^1,2, Magnus Röding^1,3, Aila Särkkä³

¹Unit Product Design, Department Agriculture and Food, Division Bioeconomy and Health, RISE Research Institute of Sweden, Gothenburg, Sweden. pierre.carmona@ri.se.

|March 12, 2021

Summary

Researchers studied porous ethylcellulose (EC) and hydroxypropylcellulose (HPC) films for drug release. They found spin-coating parameters and polymer ratios precisely control film structure and thickness, enabling tailored drug delivery systems.

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Area of Science:

Materials Science and Engineering
Polymer Science
Pharmaceutical Sciences

Background:

Porous ethylcellulose (EC) and hydroxypropylcellulose (HPC) films are crucial for controlled drug release.
The structure of these films dictates drug transport kinetics.
Understanding the dynamic evolution of porous structures during film formation is limited.

Purpose of the Study:

To investigate the structure evolution of phase-separated spin-coated EC/HPC films.
To determine the influence of spin-coating parameters and EC:HPC ratio on film morphology and thickness.
To establish control over the characteristic length scale and thickness of EC/HPC films.

Main Methods:

Utilized spin-coating to mimic industrial thin film manufacturing.
Employed confocal laser scanning microscopy (CLSM) and image analysis to study structure evolution.
Measured film thickness using profilometry and analyzed phase separation using Fourier image analysis.

Main Results:

Observed phase-separated structures consistent with spinodal decomposition.
Demonstrated that decreasing spin speed and increasing HPC ratio increase the characteristic length scale.
Found film thickness decreases with increasing spin speed, correlating with the Meyerhofer equation.

Conclusions:

Spin-coating parameters and EC:HPC ratio offer precise control over EC/HPC film morphology and thickness.
The study provides a foundation for understanding EC/HPC film morphology development.
Findings enhance the ability to engineer thin EC/HPC films for tailored drug release applications.