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Related Experiment Video

Updated: Nov 13, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Diffusion tensor imaging analysis in three progressive supranuclear palsy variants.

Jennifer L Whitwell1, Nirubol Tosakulwong2, Heather M Clark3

  • 1Department of Radiology, Mayo Clinic, Rochester, MN, USA. Whitwell.jennifer@mayo.edu.

Journal of Neurology
|March 12, 2021
PubMed
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This summary is machine-generated.

White matter degeneration patterns differ across progressive supranuclear palsy (PSP) variants. The body of the corpus callosum helps distinguish PSP-speech/language (PSP-SL) from other forms, aiding in diagnosis.

Area of Science:

  • Neuroimaging
  • Neurodegenerative diseases
  • White matter tract analysis

Background:

  • Progressive supranuclear palsy (PSP) presents with distinct clinical variants: Richardson's syndrome (PSP-RS), speech/language (PSP-SL), and parkinsonism (PSP-P).
  • Underlying white matter tract degeneration patterns and their diagnostic utility across PSP variants remain unclear.

Purpose of the Study:

  • To investigate and compare white matter tract degeneration patterns in different clinical variants of PSP.
  • To assess the potential of diffusion tensor imaging (DTI) metrics to differentiate between PSP variants.

Main Methods:

  • Diffusion tensor imaging (DTI) was performed on 49 PSP patients across three variants (PSP-RS, PSP-P, PSP-SL).
  • Regional DTI metrics were analyzed using Bayesian linear mixed-effects models.
Keywords:
Diffusion tensor imagingPSP with predominant parkinsonismPSP with speech/languageRichardson syndromeWhite matter

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  • Area under the receiver operator characteristic curve (AUROC) was used to evaluate inter-variant differentiation.

    • Main Results:

    • All PSP variants exhibited degeneration in key white matter tracts, including the corpus callosum and superior cerebellar peduncle.
    • PSP-SL showed significantly greater degeneration in the corpus callosum and superior longitudinal fasciculus compared to other variants.
    • Fractional anisotropy in the corpus callosum body effectively differentiated PSP-SL from PSP-P and PSP-RS (AUROC > 0.91).

    Conclusions:

    • Distinct white matter degeneration patterns are associated with different clinical presentations of PSP.
    • The body of the corpus callosum shows promise as a biomarker for differentiating PSP-SL from other PSP variants.