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Related Concept Videos

Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

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Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
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Drug Abuse and Addiction: Pharmacological Phenomena01:15

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Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
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Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacovigilance01:19

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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
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Related Experiment Video

Updated: Nov 13, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Prescriber perspectives on low-value prescribing: A qualitative study.

Eric L Walter1, Alicia Dawdani2, Alison Decker2

  • 1Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Journal of the American Geriatrics Society
|March 12, 2021
PubMed
Summary
This summary is machine-generated.

Primary care physicians recognize low-value prescribing in older adults as common. Interventions to reduce it must address patient, prescriber, and system factors, minimizing physician burden.

Keywords:
deprescribinglow-value caremedication valuepolypharmacy

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Area of Science:

  • Geriatric Medicine
  • Health Services Research
  • Primary Care

Background:

  • Health systems aim to decrease low-value medication use in older adults.
  • Physician perspectives on medication value and interventions are not well understood.

Purpose of the Study:

  • To identify factors influencing medication value and low-value prescribing from primary care physicians' viewpoints.
  • To understand physician perspectives on interventions aimed at reducing low-value prescribing.

Main Methods:

  • Qualitative study utilizing semi-structured interviews.
  • Sixteen primary care physicians from academic and community practices participated.

Main Results:

  • Low-value prescribing in older adults is common, influenced by medication and patient characteristics.
  • Causes are multifactorial, involving patients, prescribers, and health systems, leading to default prescribing patterns.
  • Acceptable interventions must minimize cognitive load and time pressures; increased documentation is less favored.

Conclusions:

  • Low-value prescribing is a recognized issue among physicians.
  • Effective interventions require consideration of physician perspectives.
  • Addressing patient, prescriber, and health system factors is crucial for reducing low-value prescribing.