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Related Experiment Video

Updated: Nov 13, 2025

Robotic Enucleation of an Intra-Pancreatic Insulinoma in the Pancreatic Head
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[Pancreatic proinsulinoma].

A G Kriger1, S V Berelavichus1, D S Gorin1

  • 1A.V. Vishnevsky National Research Center for Surgery, Moscow, Russia.

Khirurgiia
|March 12, 2021
PubMed
Summary
This summary is machine-generated.

Proinsulinoma, a rare pancreatic tumor, causes severe hypoglycemia with normal insulin levels. Surgical treatment is the only effective method for this condition.

Keywords:
insulinomaneuroendocrine tumorpancreasproinsulinoma

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Area of Science:

  • Endocrinology
  • Oncology
  • Surgical Pathology

Background:

  • Proinsulinoma is an exceptionally rare endocrine-active neuroendocrine pancreatic tumor.
  • Characterized by increased proinsulin production leading to hypoglycemia.
  • Often presents with normal insulin levels, complicating diagnosis.

Purpose of the Study:

  • To present the clinical experience in managing patients diagnosed with proinsulinoma.
  • To highlight the differential diagnostic features of proinsulinoma.
  • To underscore the efficacy of surgical intervention.

Main Methods:

  • Retrospective analysis of 10 patients with elevated proinsulin and normal insulin levels.
  • Clinical presentation and biochemical data were reviewed.
  • Surgical outcomes were assessed, with a focus on minimally invasive approaches.

Main Results:

  • All 10 patients experienced severe fasting hypoglycemia (as low as 0.7 mmol/l).
  • Key differentiators from insulinoma included the absence of weight gain in 7 patients and significant weight loss in one.
  • All patients underwent successful surgical treatment, predominantly minimally aggressive procedures.

Conclusions:

  • Proinsulinoma requires careful differentiation from insulinoma due to distinct clinical features.
  • The absence of weight gain and normal insulin levels in hypoglycemic patients are critical indicators.
  • Surgical resection remains the sole curative treatment for proinsulinoma.