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Targeting strategies of oral nano-delivery systems for treating inflammatory bowel disease

Wenjuan Liu1, Zirong Dong1, Kaiheng Liu1

  • 1School of Pharmacy, Key Laboratory of Smart Drug Delivery of MOE, Fudan University, Shanghai 201203, China.

International Journal of Pharmaceutics
|March 12, 2021
PubMed

Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of gastrointestinal tract with rising incidence. Established treatments of IBD are characterized by significantly adverse effects, insufficient therapeutic efficacy. Employing the oral nano-drug delivery systems for targeted therapy is capable of effectively avoiding systematic absorption and increasing local drug concentration, consequently leading to decreased adverse effects and improved therapeutic outcomes. This review gives a brief profile of pathophysiological considerations in terms of developing disease-directed drug delivery systems, then focuses on mechanisms and strategies of current oral nano-drug delivery systems, including size-, enzyme-, redox-, pH-, ligand-receptor-, mucus-dependent systems, and proposes the future directions of managements for IBD.

Keywords:
Inflammatory bowel diseaseMechanismsNano-delivery systemsOral administrationTargeting strategies

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