Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences01:20

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences

843
Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
843
Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

1.1K
The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
1.1K
Mass Analyzers: Overview01:13

Mass Analyzers: Overview

1.3K
The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lung ion-fluoroscopy Guided Hadron therapy: LIGHT concept and proof-of-principle.

Physics in medicine and biology·2026
Same author

Diagnostic accuracy of a 'stage-gated' approach for reporting prostate screening MRI: "Is less more?"

European radiology·2026
Same author

AI-powered immune profiling from histopathology slides for chemo-radiotherapy outcome prediction in rectal cancer: a study using clinical trial and real-world cohorts.

EBioMedicine·2025
Same author

A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides.

Communications biology·2024
Same author

Ion and secondary imaging.

Physics in medicine and biology·2024
Same author

Imaging lung tumor motion using integrated-mode proton radiography-A phantom study towards tumor tracking in proton radiotherapy.

Medical physics·2024
Same journal

Effective contrast-enhanced preprocessing for intracranial artery segmentation in digital subtraction angiography.

Physics in medicine and biology·2026
Same journal

Improving Plan Quality in Adaptive Proton Therapy Using an Interactive Dose Modification Tool.

Physics in medicine and biology·2026
Same journal

Technical Note: Real-Time MLC Control and Latency Measurement Optimization with External Verification.

Physics in medicine and biology·2026
Same journal

Fetus-Specific Hematopoietic Stem Cell Dosimetry Framework for Leukemia-Relevant Target Cells During Prenatal Development.

Physics in medicine and biology·2026
Same journal

Deep learning-based dose prediction to enhance planning efficiency in cervical brachytherapy with hybrid applicators.

Physics in medicine and biology·2026
Same journal

Corrigendum: Referenceless MR thermometry-a comparison of five methods (2017<i>Phys. Med. Biol</i>.<b>62</b>1-16).

Physics in medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Nov 13, 2025

3D Depth Profile Reconstruction of Segregated Impurities Using Secondary Ion Mass Spectrometry
07:10

3D Depth Profile Reconstruction of Segregated Impurities Using Secondary Ion Mass Spectrometry

Published on: April 29, 2020

1.9K

Statistical limitations in ion imaging.

Charles-Antoine Collins-Fekete1,2, Nikolaos Dikaios3, Esther Bär1

  • 1Department of Medical Physics and Biomedical Engineering, University College London, Gower Street, London, United Kingdom.

Physics in Medicine and Biology
|March 12, 2021
PubMed
Summary
This summary is machine-generated.

Protons offer superior signal-to-noise ratio (SNR) for radiotherapy imaging but lower spatial resolution. Carbon ions provide better resolution, highlighting a trade-off between image quality metrics for different ion beams.

Keywords:
ion tomographyparticle imagingrange uncertainty

More Related Videos

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
15:10

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat

Published on: December 28, 2013

7.2K
Imaging Corrosion at the Metal-Paint Interface Using Time-of-Flight Secondary Ion Mass Spectrometry
07:24

Imaging Corrosion at the Metal-Paint Interface Using Time-of-Flight Secondary Ion Mass Spectrometry

Published on: May 6, 2019

8.5K

Related Experiment Videos

Last Updated: Nov 13, 2025

3D Depth Profile Reconstruction of Segregated Impurities Using Secondary Ion Mass Spectrometry
07:10

3D Depth Profile Reconstruction of Segregated Impurities Using Secondary Ion Mass Spectrometry

Published on: April 29, 2020

1.9K
A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
15:10

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat

Published on: December 28, 2013

7.2K
Imaging Corrosion at the Metal-Paint Interface Using Time-of-Flight Secondary Ion Mass Spectrometry
07:24

Imaging Corrosion at the Metal-Paint Interface Using Time-of-Flight Secondary Ion Mass Spectrometry

Published on: May 6, 2019

8.5K

Area of Science:

  • Medical Physics
  • Radiotherapy Imaging
  • Ion Beam Applications

Background:

  • Relative stopping power (RSP) maps are crucial for accurate radiotherapy planning.
  • Optimizing image quality metrics like SNR and spatial resolution is essential for effective treatment.
  • Different ion beams (H, He, Li, B, C) have varying physical properties impacting imaging.

Purpose of the Study:

  • To evaluate the image quality of different ion beams for RSP mapping in radiotherapy.
  • To compare signal-to-noise ratio (SNR) and spatial resolution across various ions.
  • To determine the optimal ion for high-quality RSP imaging.

Main Methods:

  • Utilized Geant4 Monte Carlo simulations for H, He, Li, B, and C ion beams.
  • Simulated ion beams passing through a 20 cm diameter water phantom.
  • Analyzed energy-loss measurements to determine RSP maps and image quality metrics.

Main Results:

  • Protons exhibited significantly higher SNR (up to 36% higher than helium) due to nuclear stability and low dose per primary.
  • Protons yielded the lowest spatial resolution, four times lower than carbon imaging at the same range.
  • Carbon ions provided the highest image quality metrics when spatial resolution was fixed at 10 lp cm⁻¹.

Conclusions:

  • No single ion beam can simultaneously optimize all image quality metrics (SNR, spatial resolution, dose).
  • A trade-off exists between achieving high SNR and high spatial resolution when selecting ion beams.
  • The choice of ion beam in radiotherapy imaging necessitates a balance between desired resolution and signal quality.