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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...

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Related Experiment Video

Updated: Jul 25, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

[Primary cancer of the appendix].

G Schwesinger1, L Riethdorf, H Scülfort

  • 1Institut für Pathologische Anatomie, Ernst-Moritz-Arndt-Universität Greifswald.

Deutsche Zeitschrift Fur Verdauungs- Und Stoffwechselkrankheiten
|January 1, 1988
PubMed
Summary

This case report details an appendix carcinoma discovered during autopsy in a 58-year-old man. It highlights the diagnostic challenges and rarity of this malignancy.

Area of Science:

  • Oncology
  • Pathology
  • Surgical Pathology

Background:

  • Appendiceal carcinoma is a rare gastrointestinal malignancy.
  • Diagnosis can be challenging due to nonspecific symptoms and rarity.

Observation:

  • A case of appendiceal carcinoma in a 58-year-old male is presented.
  • The diagnosis was established post-mortem via autopsy.
  • Key aspects discussed include histological classification and metastatic patterns.

Findings:

  • The report discusses the rarity and diagnostic difficulties associated with appendiceal carcinoma.
  • Metastasis and differential diagnosis challenges are highlighted.
  • Therapeutic strategies are briefly considered in the context of this rare cancer.

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Implications:

  • This case underscores the importance of considering rare diagnoses in clinical practice.
  • Understanding the pathology and diagnostic pitfalls of appendiceal carcinoma is crucial.
  • Further research into early detection and treatment of appendiceal neoplasms is warranted.