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Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
Potential role of tocilizumab in severe gastrointestinal barrier damage after CAR T-cell therapy
David Beauvais1, Oriane Karleskind2, Severine Loridant3
1Univ. Lille, CHU Lille, Department of Haematology, F-59000, Lille, France.
Abstract:
We report a septicemia and disseminated candidiasis due to delayed gastrointestinal mucosae repair in a patient treated with tocilizumab after anti-CD19 CAR T-cell therapy. Tocilizumab could have inhibited intestinal tissue repair and furthered bacteria translocation leading to the invasion of intestinal mucosa by yeasts as IL-6 is known to be involved in mucosal wound healing.
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