Related Experiment Video

Updated: Nov 13, 2025

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice
15:45

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Published on: February 10, 2013

18.5K

Dobutamine stress testing for the evaluation of atrial and diastolic ventricular function in Fontan patients

Jelle P G van der Ven1,2, Sjoerd S M Bossers1, Eva van den Bosch1,2

  • 1Pediatric Cardiology, Erasmus MC Sophia Children Hospital, Rotterdam, Zuid-Holland, The Netherlands.

Open Heart
|March 13, 2021
PubMed

Insights

Dobutamine stress improved atrial function in Fontan patients, with atrial early emptying reserve linked to exercise capacity in extracardiac conduit (ECC) Fontan survivors. No other diastolic function parameters predicted outcomes.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Cardiac Physiology

Background:

  • Fontan-associated pathway dysfunction affects long-term outcomes.
  • Assessing cardiac function in Fontan patients is crucial for risk stratification.

Purpose of the Study:

  • To evaluate atrial and ventricular diastolic function response to dobutamine stress in Fontan patients.
  • To correlate these functional parameters with exercise capacity and clinical events.

Main Methods:

  • Secondary analysis of a multicenter study involving 57 Fontan patients (intra-atrial lateral tunnel [ILT] or extracardiac conduit [ECC]).
  • Cardiac MRI during rest and dobutamine stress, cardiopulmonary exercise testing.
  • Correlation and Cox proportional hazards models to assess relationships between dobutamine response, exercise capacity, and outcomes.

Main Results:

  • Dobutamine stress increased atrial cyclic volume change, early, and late emptying volumes (p<0.001).
  • Ventricular early filling decreased (p=0.046) and late filling increased (p<0.001).
  • Atrial early emptying volume increase correlated with peak oxygen uptake in ECC patients (ρ=0.66, p=0.002); no other parameters related to exercise capacity or predicted outcomes.

Conclusions:

  • Dobutamine stress enhances atrial reservoir and pump function in Fontan patients.
  • Atrial early emptying reserve is associated with exercise capacity in ECC patients.
  • No significant correlation found between other atrial or ventricular diastolic function parameters and exercise capacity or long-term outcomes.
Abstract

Keywords:
congenitalfontan procedureheart defectsmagnetic resonance imaging

More Related Videos

Functional Assessment of the Donor Heart During Ex Situ Perfusion: Insights from Pressure-Volume Loops and Surface Echocardiography08:21

Functional Assessment of the Donor Heart During Ex Situ Perfusion: Insights from Pressure-Volume Loops and Surface Echocardiography

Published on: October 11, 2022

2.3K
Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring06:29

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring

Published on: May 2, 2025

447

Related Concept Videos

Exercise Stress Test01:26

Exercise Stress Test

Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
675
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
78
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
134