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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

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Related Experiment Video

Updated: Nov 13, 2025

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

Advanced imaging and labelling methods to decipher brain cell organization and function.

Daniel Choquet^1,2, Matthieu Sainlos³, Jean-Baptiste Sibarita⁴

¹University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, Bordeaux, France. daniel.choquet@u-bordeaux.fr.

Nature Reviews. Neuroscience

|March 13, 2021

Summary

This summary is machine-generated.

Advanced imaging techniques and molecular tools are revolutionizing neuroscience. These innovations overcome challenges in visualizing complex brain structures and functions, paving the way for deeper understanding of the brain.

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A Rapid Approach to High-Resolution Fluorescence Imaging in Semi-Thick Brain Slices

A Rapid Approach to High-Resolution Fluorescence Imaging in Semi-Thick Brain Slices

Published on: July 26, 2011

Related Experiment Videos

Last Updated: Nov 13, 2025

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy

Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy

Published on: August 1, 2022

A Rapid Approach to High-Resolution Fluorescence Imaging in Semi-Thick Brain Slices

A Rapid Approach to High-Resolution Fluorescence Imaging in Semi-Thick Brain Slices

Published on: July 26, 2011

Area of Science:

Neuroscience
Biophysics
Cell Biology

Background:

The brain's complexity, including intricate neural morphology and connectivity, poses significant challenges to understanding its function.
Neuroscience research heavily relies on technological advancements for visualization, quantification, and modification of cellular and network properties.
Recent decades have seen rapid progress in advanced imaging methods, particularly super-resolution microscopy and tissue imaging.

Purpose of the Study:

To review the latest developments in molecular tools for labeling and functionalizing proteins.
To explore how these molecular tools are integrated with advanced imaging techniques.
To highlight how these combined approaches overcome limitations in brain visualization.

Main Methods:

Development of advanced imaging methods, including super-resolution microscopy and tissue imaging.
Creation of novel molecular tools for protein labeling and functionalization using small reporters.
Integration of molecular tools with imaging techniques to surpass diffraction limits and increase tissue penetration depth.

Main Results:

Innovations in instrumentation have led to breakthroughs in microscopy and tissue imaging.
New molecular strategies enable precise targeting and functionalization of proteins within cells.
Combined approaches allow for unprecedented visualization of brain structures and functions.

Conclusions:

The synergy between advanced imaging and molecular tools is transforming the study of the brain.
These developments promise significant advancements in understanding brain complexity and function.
Future research will benefit from these powerful techniques for exploring neural circuits and cellular processes.