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Updated: Nov 13, 2025

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
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Published on: April 6, 2012

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Targets and regulation of microRNA-652-3p in homoeostasis and disease

Maxwell T Stevens1, Bernadette M Saunders2,3

  • 1School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.

Journal of Molecular Medicine (Berlin, Germany)
|March 13, 2021
PubMed

Insights

MicroRNA-652-3p regulates cell functions and is implicated in various diseases. This microRNA shows promise as a diagnostic biomarker and therapeutic target due to its broad cellular activity.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression by inhibiting mRNA translation.
  • miRNAs are increasingly recognized for their roles in cellular homeostasis and disease pathogenesis.
  • miR-652-3p is a specific miRNA with emerging roles in diverse physiological and pathological processes.

Purpose of the Study:

  • To review the current literature on microRNA-652-3p (miR-652-3p).
  • To discuss the known target genes of miR-652-3p and their relevance to disease progression.
  • To highlight the potential of miR-652-3p as a diagnostic and therapeutic target.

Main Methods:

  • Literature review of studies investigating miR-652-3p.
  • Analysis of reported target genes and their functional implications.
  • Synthesis of findings related to miR-652-3p's role in cancer, cardiovascular, mental health, and CNS diseases.

Main Results:

  • miR-652-3p targets LLGL1 and ZEB1, influencing cell polarity, cancer metastasis, and asymmetric cell division.
  • miR-652-3p inhibits JAG1, impacting angiogenesis and immune cell regulation.
  • Dysregulation of miR-652-3p is linked to multiple pathways involved in disease states.

Conclusions:

  • miR-652-3p plays diverse roles in normal cell function and disease.
  • Its ability to modulate key cellular processes makes it a significant research focus.
  • miR-652-3p demonstrates considerable potential as a biomarker and therapeutic agent.
Keywords:
CancerCardiovascular diseaseMental healthNotch signallingmiR-652

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