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Phrynoderma: is it an EFA deficiency disease?

Ghafoorunissa1, R Vidyasagar, K Krishnaswamy

  • 1National Institute of Nutrition, Indian Council of Medical Research, Hyderabad.

European Journal of Clinical Nutrition
|January 1, 1988
PubMed
Summary

Phrynoderma treatment showed vitamin B-complex was most effective, with complete response in under six weeks. Essential fatty acid levels were normal in most patients, suggesting phrynoderma isn't directly caused by EFA deficiency.

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Area of Science:

  • Dermatology
  • Nutritional Science
  • Biochemistry

Background:

  • Phrynoderma is a skin condition with unclear etiology.
  • Previous studies suggested a link to essential fatty acid (EFA) deficiency.
  • Therapeutic responses in phrynoderma patients vary.

Purpose of the Study:

  • To evaluate the clinical response to vitamin B-complex, vitamin E, and safflower oil in phrynoderma patients.
  • To assess the essential fatty acid (EFA) nutriture in patients with phrynoderma.
  • To investigate the relationship between EFA status and phrynoderma.

Main Methods:

  • Clinical evaluation of 31 phrynoderma patients receiving different treatments.
  • Biochemical analysis of plasma phospholipid fatty acid composition in 30 patients and 7 controls.
  • Comparison of EFA status between patient groups and controls.

Main Results:

  • Vitamin B-complex resulted in complete clinical response in an average of 5.7 weeks.
  • Vitamin E and safflower oil showed partial or total improvement over 10-13 weeks.
  • Most phrynoderma patients (Pattern A) had normal EFA levels and metabolism, unlike a smaller group (Pattern B).
  • EFA status did not correlate with clinical features or treatment response.

Conclusions:

  • Phrynoderma may not be directly linked to essential fatty acid deficiency.
  • Vitamin B-complex appears to be a highly effective treatment for phrynoderma.
  • Plasma phospholipid fatty acid profiles do not reliably indicate clinical status or therapeutic outcomes in phrynoderma.

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