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The MPLEx Protocol for Multi-omic Analyses of Soil Samples

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Dengue and metabolomics in humans.

Alexandre Giannecchini Romagnolo¹, Karina Inacio Carvalho^2,3

¹Hospital Israelita Albert Einstein, São Paulo, Brazil.

Metabolomics : Official Journal of the Metabolomic Society

|March 13, 2021

Summary

Metabolomic studies reveal how dengue virus impacts human metabolism. This research offers new molecular insights into dengue fever, a disease with no current treatments or vaccines.

Keywords:

Dengue fever Human samples Metabolomic

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Area of Science:

Infectious diseases
Metabolomics
Molecular biology

Background:

Dengue virus causes dengue fever (DF), a severe mosquito-borne illness with no available treatments or vaccines.
Global warming is expanding the range of the Aedes aegypti mosquito, increasing dengue's public health threat.
Metabolomics offers a novel molecular perspective for understanding DF pathogenesis.

Purpose of the Study:

To review how dengue virus infection affects human metabolomic profiles.
To focus on studies using human samples and cell cultures, rather than animal models.

Main Methods:

Compilation of sample sources used in metabolomic studies of dengue.
Identification of metabolomic techniques employed in DF research.
Analysis of detected metabolites and their alterations across different DF stages.

Main Results:

Dengue infection significantly alters numerous metabolites in humans.
Metabolomic profiling reveals distinct metabolic changes associated with DF.
Conflicting results exist between studies, highlighting the need for further research.

Conclusions:

Metabolomic approaches are valuable for advancing DF knowledge.
Understanding metabolic alterations can lead to new diagnostic or therapeutic strategies.
Further research is needed to resolve conflicting findings and fully elucidate DF's molecular mechanisms.