Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Acute Respiratory Failure-II

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Activity of a three-phage combination against <i>Mycobacterium tuberculosis</i> in disease-relevant conditions.

bioRxiv : the preprint server for biology·2026

Same author

Serial assessment of modified Society for Cardiovascular Angiography and Interventions SHOCK classification in post-cardiotomy patients.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026

Same author

[Clinical characteristics and genetic spectrum of adults with primary ciliary dyskinesia].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2026

Same author

[One case of cataract caused by occupational trinitrotoluene].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2026

Same author

Treatment of catheter related thrombosis: A systematic review, meta-analysis, and national survey.

Journal of vascular surgery. Venous and lymphatic disorders·2025

Same author

Thrombectomy in high-risk pulmonary embolism - device versus thrombolysis: rationale and design of the TORPEDO-NL investigator-initiated, academically-sponsored, multicenter, open-label randomized controlled trial.

Thrombosis research·2025

Same journal

Publisher Correction: Current knowledge and challenges of sepsis-associated encephalopathy.

Intensive care medicine·2026

Same journal

Prehospital airway and ventilatory management: a collaborative and narrative review.

Intensive care medicine·2026

Same journal

Rapid coma with bilateral basal ganglia involvement.

Intensive care medicine·2026

Same journal

From size to function: moving beyond body mass index to frailty and central adiposity phenotypes.

Intensive care medicine·2026

Same journal

Effects of a clinical metagenomics intervention on clinical outcomes, healthcare costs, and health-related quality of life in patients with sepsis or septic shock: results of the randomized-controlled DigiSep trial.

Intensive care medicine·2026

Same journal

Hypercalcemia in intensive care unit: pathophysiological mechanisms and clinical implications.

Intensive care medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 13, 2025

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

Published on: November 26, 2018

Between-trial heterogeneity in ARDS research.

J Juschten^1,2,3, P R Tuinman^4,5, T Guo^4,5,6

¹Department of Intensive Care, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, mail stop ZH 7D-172, 1081HV, Amsterdam, The Netherlands. j.juschten@amsterdamumc.nl.

Intensive Care Medicine

|March 13, 2021

Summary

This summary is machine-generated.

Acute respiratory distress syndrome (ARDS) randomized controlled trials (RCTs) show significant heterogeneity in outcomes and reporting. Standardized reporting of patient characteristics is crucial for improving the generalizability of ARDS research.

Keywords:

ARDS Critical Care Research Heterogeneity

More Related Videos

Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome

Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome

Published on: October 26, 2018

Experimental Model to Evaluate Resolution of Pneumonia

Experimental Model to Evaluate Resolution of Pneumonia

Published on: February 17, 2023

Related Experiment Videos

Last Updated: Nov 13, 2025

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

Published on: November 26, 2018

Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome

Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome

Published on: October 26, 2018

Experimental Model to Evaluate Resolution of Pneumonia

Experimental Model to Evaluate Resolution of Pneumonia

Published on: February 17, 2023

Area of Science:

Critical Care Medicine
Pulmonary Medicine
Clinical Trial Methodology

Background:

Randomized controlled trials (RCTs) for acute respiratory distress syndrome (ARDS) often yield conflicting results.
Lung-protective ventilation strategies are standard, yet trial outcomes remain variable.

Approach:

A systematic review and meta-regression analysis of 67 RCTs involving adult ARDS patients (2000-2019) using lung-protective ventilation.
Quantified between-trial heterogeneity in reporting standards and 28-day control-group mortality.
Evaluated trial and patient characteristics as sources of heterogeneity.

Key Points:

Significant heterogeneity (I²=88%) was observed in 28-day control-group mortality (10-67%).
Incomplete reporting of baseline patient characteristics (only 9% reported all four key variables) contributed to outcome variability.
Residual heterogeneity in mortality ranged from 18-45% after adjustment for patient factors.
Trials showing significant benefit had higher control group mortality (44%) compared to indeterminate/harm trials (28%).

Conclusions:

Substantial unexplained heterogeneity exists in ARDS RCTs, impacting generalizability.
Urgent need for standardized reporting of trial and baseline characteristics in ARDS research.
Improved reporting standards are essential for robust and reproducible clinical trial findings.